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AP&T:使用基于粪便细菌标记物的特征的检测手法可减少粪便免疫化学测试假阳性结果

2019-05-19 不详 MedSci原创

结直肠癌是癌症死亡原因的第二大常见病因。一些国家正在使用非侵入性工具(如粪便免疫化学试验)实施结直肠癌筛查,以期望早期检测到癌症病变,但该试验显示对癌前病变的敏感性较低,对结直肠癌的阳性预测值较低,因此导致假阳性率较高。本项研究旨在开发基于细菌粪便生物标志物新的非侵入性结直肠癌筛查方法,其与粪便免疫化学试验相结合,可以降低假阳性率。该工具被称为结直肠癌肠道疾病的风险评估模型(RAID-CRC)。

背景
直肠癌是癌症死亡原因的第二大常见病因。一些国家正在使用非侵入性工具(如粪便免疫化学试验)实施直肠癌筛查,以期望早期检测到癌症病变,但该试验显示对癌前病变的敏感性较低,对结直肠癌的阳性预测值较低,因此导致假阳性率较高。本项研究旨在开发基于细菌粪便生物标志物新的非侵入性结直肠癌筛查方法,其与粪便免疫化学试验相结合,可以降低假阳性率。该工具被称为结直肠癌肠道疾病的风险评估模型(RAID-CRC)。

方法
研究人员收集来自正常结肠镜检查(167),非晚期腺瘤(88),晚期腺瘤(30)和结肠直肠癌(48)的个体的粪便样品中进行了粪便免疫化学测试和细菌标记物分析(RAID-CRC测试)。

结果
通过使用加泰罗尼亚(20μgHb/ g)中建立的临界值来确定晚期肿瘤(即晚期腺瘤和结肠直肠癌)的粪便免疫化学试验的性能,敏感性和特异性值分别为83%和80%,阳性和阴性预测值分别为56%和94%。当组合免疫学和生物学分析时,敏感性和特异性的相应值分别为80%和90%,阳性和阴性预测值分别为70%和94%。

结论
RAID-CRC测试可以显着降低有症状人群的粪便免疫化学测试假阳性结果(50%)。

原始出处:

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    2020-04-14 wjywjy
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topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-24 王秀

    学习了,涨知识了!

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Thu May 23 22:01:15 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366654, encodeId=1c1236665490, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Thu May 23 15:39:04 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366599, encodeId=c9a036659970, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, 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encodeId=16ed1392650ad, content=<a href='/topic/show?id=89412e60158' target=_blank style='color:#2F92EE;'>#假阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27601, encryptionId=89412e60158, topicName=假阳性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKJUlpK5asKgfVAGEUnO6CbNf6icCfycdBO2zX5TWJq27yt434nFicdjf7OsvbOZBOotQdNx6J6PaZQ/132, createdBy=fcba2500108, createdName=ms6519009802973839, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466858, encodeId=e1831466858ea, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-23 王秀

    学习了,涨知识了!

    0

  5. 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topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-23 王秀

    学习了,涨知识了!

    0

  6. 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encodeId=16ed1392650ad, content=<a href='/topic/show?id=89412e60158' target=_blank style='color:#2F92EE;'>#假阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27601, encryptionId=89412e60158, topicName=假阳性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKJUlpK5asKgfVAGEUnO6CbNf6icCfycdBO2zX5TWJq27yt434nFicdjf7OsvbOZBOotQdNx6J6PaZQ/132, createdBy=fcba2500108, createdName=ms6519009802973839, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466858, encodeId=e1831466858ea, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-22 王秀

    学习了,涨知识了!

    0

  7. 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topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-21 王秀

    学习了,涨知识了!

    0

  8. 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  9. 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topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Tue May 21 12:19:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366515, encodeId=8b3f366515b3, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 20 20:22:04 CST 2019, time=2019-05-20, status=1, ipAttribution=)]
    2019-05-21 Homburg
  10. 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    2019-05-20 王秀

    学习了,涨知识了!

    0

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