Baidu
map

Heart:心尖肥厚型心肌病患者心腔闭塞预后不佳

2016-03-13 QQduhp 译 MedSci原创

目的心尖肥厚型心肌病(HCM)患者出现心房纤颤(AF)、卒中、心力衰竭(HF)和死亡的风险增加。该研究的目的在于探究左心室(LV)顶端闭塞是否对HCM患者的病情发展和预后有不利影响。 方法188名患有心尖肥厚型心肌病的患者(114名为男性,平均年龄为67岁)参与研究,研究人员于2008年1月-2010年12月开展了回顾性研究。 心尖闭塞率依据心室舒张末期心尖厚度而定,心腔闭塞率依据心室收缩末期心腔

目的:心尖肥厚型心肌病(HCM)患者出现心房纤颤(AF)、卒中、心力衰竭(HF)和死亡的风险增加。该研究的目的在于探究左心室(LV)顶端闭塞是否对HCM患者的病情发展和预后有不利影响。 


方法:188名患有心尖肥厚型心肌病的患者(114名为男性,平均年龄为67岁)参与研究,研究人员于2008年1月-2010年12月开展了回顾性研究。心尖闭塞率依据心室舒张末期心尖厚度而定,心腔闭塞率依据心室收缩末期心腔高度而定。研究人员关注的主要结果是房颤、卒中、心力衰竭、心血管疾病死亡率的发生率。

结果:在4.4年的随访期间共发生了43例主要结果事件(19例房颤、11例心力衰竭、9例卒中、4例死亡),发生主要结果事件的患者均年迈、左心室容积指数(LAVI)较大、左心室舒张压较大、舒张晚期二尖瓣环组织多普勒流速较小。他们心尖肥厚和闭塞较为明显,心室收缩末期心腔高度较低,心尖闭塞率和心腔闭塞率更高。心尖闭塞率和心腔闭塞率较高的前1/3患者发生不良结果的发生率更高,占54%。年龄、 E/e′、a′、LAVI、心尖厚度、心尖闭塞率和心腔闭塞率等与不良结果发生率明显相关。在多变量分析中,心腔闭塞率仍然是一个重要的预测指标。

结论:研究人员认为,心腔闭塞率是预测HCM不良事件发生率的有效指标。

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]
    2017-02-08 okhuali
  2. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]
    2016-03-24 1ddc978cm67(暂无匿称)

    谢谢分享。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]
    2016-03-22 1de304d2m86(暂无匿称)

    学习了,了解了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]
    2016-03-14 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]
    2016-03-14 slcumt
  6. [GetPortalCommentsPageByObjectIdResponse(id=1769333, encodeId=cc791e69333a1, content=<a href='/topic/show?id=beb9509e872' target=_blank style='color:#2F92EE;'>#心尖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50978, encryptionId=beb9509e872, topicName=心尖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a9138017074, createdName=okhuali, createdTime=Wed Feb 08 13:32:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73088, encodeId=7b3ae3088d1, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Thu Mar 24 06:52:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72686, encodeId=92a4e268617, content=学习了,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Tue Mar 22 13:09:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356062, encodeId=f74313560628c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562361, encodeId=2f8115623617c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622231, encodeId=6d0f16222317f, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 14 23:32:00 CST 2016, time=2016-03-14, status=1, ipAttribution=)]

相关资讯

JCMM:HIF-1α激活瞬时受体TRPC通道促进轻度缺氧心肌细胞肥大

近日,国际著名杂志《细胞与分子医学期刊》(Journal of Cellular and Molecular Medicine)发表了哈尔滨医科大学的一项研究成果,首次证实了轻度缺氧HIF-1α可以调控心肌肥厚,可望为生理性或病理性心肌肥厚的防治提供新的靶点和药物干预策略。 这篇题为《缺氧诱导因子HIF-1α激活瞬时受体TRPC通道促进轻度缺氧心肌细胞肥大》的论文是哈医大药学院青年专家初文峰教授

J. Cell. Mol. Med:杨宝峰等发现缺氧调控心肌肥厚新机制

近日,国际著名杂志《细胞与分子医学期刊》(Journal of Cellular and Molecular Medicine)发表了哈尔滨医科大学的一项研究成果,首次证实了轻度缺氧HIF-1α可以调控心肌肥厚,可望为生理性或病理性心肌肥厚的防治提供新的靶点和药物干预策略。 这篇题为《缺氧诱导因子HIF-1α激活瞬时受体TRPC通道促进轻度缺氧心肌细胞肥大》的论文是哈医大药学院青年专家初文峰教授

郭继鸿:心电学2015四大新近进展

6月14日在河北沧州举办的第四届中国基层心血管病大会上,来自北京大学人民医院的郭继鸿教授针对心电学的4项最新进展做了精彩演讲,分别为Holter初筛睡眠呼吸暂停综合征、体表三维标测技术、遗传性心律失常新分类和假性心肌肥厚。一、Holter初筛睡眠呼吸暂停综合征(SAS)SAS是指在睡眠8h中,呼吸反复暂停,使人体发生系列病理生理改变的临床综合征。可分

APJ受体作为心肌细胞压力感受器诱导心肌肥厚的形成

 最近来自美国桑福德-伯纳姆医学研究所和斯坦福大学医学院的研究人员报道了apelin/APJ系统在心肌肥 厚形成中存在双重调控作用及其可能的调控机制。相关研究论文“APJ acts as a dual receptor in cardiac hypertrophy”于2012年8月16号发表在nature第488卷(394–398)杂志上,该报道首次提出apelin-血管紧张素样受

Circulation :非那雄胺(抗雄激素治疗):为心衰治疗提供新思路

目前慢性心衰治疗的患者,死亡率仍旧居高不减,然而,人们却往往忽视了一个重要的差别,那就是女性心衰患者相对于男性而言,死亡率要来的低。性激素或许可以为这个差别作出一定的解释,尤其是雄激素和雌激素在心衰患者中的表达,暗示着两者可能直接作用于心肌。 5α-还原酶能够将睾酮转换成二氢睾酮(其作用是睾酮的10倍),而非那雄胺能够抑制5α-还原酶。德国汉诺威医学院Zwadlo C等人研究了非那雄

J Pathol:南京大学发现心肌肥厚中关键酶分子

最近,南京大学模式动物研究所李朝军教授课题组在心脏病的分子病理学研究上取得了新突破。他们发现牛耳基焦磷酸合成酶(GGPPS),一种蛋白质异戊二烯化的关键酶,在心肌肥厚小鼠模型中明显下调。 高灵敏度LC-MS/MS分析揭露了心肌细胞中法尼基焦磷酸(FPP)和牛耳基焦磷酸(GGPP)之间的平衡被打破是小鼠心肌肥厚的重要诱因。心脏组织特异性敲除GGPPS,会诱发小鼠心肌肥厚,并使其在出生2个月后死于

Baidu
map
Baidu
map
Baidu
map