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JAHA:清晨高血压是否与血管靶器官损害及中心血流动力学有关?

2017-02-15 xing.T MedSci原创

清晨高血压,尤其是与夜间高血压相关的清晨高血压,与较高的中心血压和动脉硬化程度增加有关。进一步研究将明确伴有或不伴夜间高血压的清晨高血压是否与临床预后有关。

最近的一项研究报告表明清晨高血压高血压患者的心血管不良预后有关。然而,目前还不清楚是否清晨高血压与持续性夜间高血压有关,并且清晨血压(BP)激增对心血管靶器官损害和临床结局是否存在不同影响。近日,心血管疾病领域权威杂志JAHA上针对这一临床问题发表了一篇研究文章。该研究旨在明确高心血管疾病风险的高血压患者心血管疾病的靶器官损害以及中心血流动力学与清晨高血压伴有夜间/无夜间高血压之间的相关性。

研究人员对1070例连续就诊的高心血管疾病风险的参与者进行了动态血压监测和中心血压测定。研究人员将清晨高血压患者分成以下3个亚组:(I)清晨血压正常;(II)清晨高血压但无夜间高血压;(III)清晨高血压同时伴有夜间高血压。

研究人员发现清晨高血压患者有469例(43.8%),清晨高血压同时伴有夜间高血压的患者有374例(34.9%)。相比于I、II组的患者,III组的患者中心收缩压、舒张压、颈动脉股动脉脉搏波传导速度均明显升高(所有P<0.001)。III型(相比于Ⅰ型)是中心高血压和高风险动脉硬化的独立预测因子(分别为P<0.001,P=0.018),而在充分调整的模型(模型Y)中并不是血管损伤的预测因子。

由此可见,清晨高血压,尤其是与夜间高血压相关的清晨高血压,与较高的中心血压和动脉硬化程度增加有关。进一步研究将明确伴有或不伴夜间高血压的清晨高血压是否与临床预后有关。

原始出处:


Jaewon Oh, et al. Association of Morning Hypertension Subtype With Vascular Target Organ Damage and Central Hemodynamics. JAHA.2017. https://doi.org/10.1161/JAHA.116.005424

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    2017-07-17 habb
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    2017-02-17 zhaohui6731
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