Baidu
map

NEJM:氢化可的松可提高无支气管肺发育不良患者的生存率

2022-03-27 MedSci原创 MedSci原创

与安慰剂相比,从出生后第14天到第28天开始使用氢化可的松治疗并没有显著提高无中度或重度支气管肺发育不良婴儿的存活率。没有中度或重度神经发育障碍婴儿的存活率在两组之间没有显著差异。

支气管肺发育不良是极早产后常见的并发症。机械通气引起的炎症可能有助于其发生发展。出生后第二周后的氢化可的松治疗是否可以提高患者生存率,而不会出现不良的支气管肺和神经发育效应,目前尚不清楚。

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员在胎龄小于30周且在14至28天时已插管至少7天的婴儿中进行了一项试验。婴儿被随机分配接受氢化可的松(4mg/kg体重/天,在10天内逐渐减少)或安慰剂治疗。次外,研究人员规定了强制拔管阈值。该研究的主要疗效结局是在月经后36周时无中度或重度支气管肺发育不良患者的生存率,该研究的主要安全性结局是在校正年龄22至26个月时无中度或重度神经发育障碍的生存率。

研究人员招募了800名婴儿(平均[±SD]出生体重为715±167g;平均胎龄为24.9±1.5周)。氢化可的松组398名婴儿中的66名(16.6%)婴儿和安慰剂组402名婴儿中的53名(13.2%)在36周时没有中度或重度支气管肺发育不良的存活(调整率比为1.27;95%置信区间[CI]为0.93至1.74)。91.0%的婴儿的两年结局是已知的。

氢化可的松治疗组358名婴儿中有132名(36.9%)和安慰剂组359名婴儿中的134名(37.3%)存活,没有中度或重度神经发育障碍(调整后的比率为0.98;95%CI为0.81至1.18)。使用氢化可的松治疗的高血压发生率高于安慰剂(4.3% vs. 1.0%)。两组的其他不良事件相似。

由此可见,在这项涉及早产儿的试验中,与安慰剂相比,从出生后第14天到第28天开始使用氢化可的松治疗并没有显著提高无中度或重度支气管肺发育不良婴儿的存活率。没有中度或重度神经发育障碍婴儿的存活率在两组之间没有显著差异。

原始出处:
 
Kristi L. Watterberg.et al.Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.NEJM.2022.https://www.nejm.org/doi/full/10.1056/NEJMoa2114897

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
    2022-03-29 刘刚94

    👍

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
    2022-03-26 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1808732, encodeId=231b1808e32c6, content=<a href='/topic/show?id=098d820866b' target=_blank style='color:#2F92EE;'>#肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82086, encryptionId=098d820866b, topicName=肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Jun 09 16:53:42 CST 2022, time=2022-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892300, encodeId=eea018923002f, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Sun Jun 26 18:53:42 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1206942, encodeId=70f512069423c, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200925/dd5e64b873f040c3b64cfac40cc3d0c2/55b921cc37474cae955de28071c846b2.jpg, createdBy=ab222317847, createdName=刘刚94, createdTime=Tue Mar 29 16:01:58 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256890, encodeId=63fc125689097, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347614, encodeId=474a134e61416, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374319, encodeId=c89b13e431947, content=<a href='/topic/show?id=33615e160c1' target=_blank style='color:#2F92EE;'>#支气管肺发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57160, encryptionId=33615e160c1, topicName=支气管肺发育不良)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=598a379, createdName=photoman, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417477, encodeId=a567141e4779b, content=<a href='/topic/show?id=09ca6395150' target=_blank style='color:#2F92EE;'>#氢化可的松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63951, encryptionId=09ca6395150, topicName=氢化可的松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88b63287356, createdName=cmj9wellington, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568019, encodeId=cf7a15680195b, content=<a href='/topic/show?id=7a833e94079' target=_blank style='color:#2F92EE;'>#发育不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37940, encryptionId=7a833e94079, topicName=发育不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b515313716, createdName=villahu, createdTime=Sat Mar 26 00:53:42 CST 2022, time=2022-03-26, status=1, ipAttribution=)]

相关资讯

NEJM:氢化可的松不能降低脓毒性休克者的死亡率

当前临床指南推荐,如果经过充足的液体复苏和升压药物治疗后,血流动力学仍不稳定的脓毒性休克患者可以给予氢化可的松治疗。但是该推荐意见基于低质量的证据,推荐水平也较弱。

NEJM:氢化可的松联合氟氢可的松降低脓毒性休克者的死亡率

脓毒性休克的特征为宿主对感染的反应失调,导致威胁生命的循环、细胞和代谢异常。短期死亡率为45-50%,50%的幸存者将遗留长期认知功能下降。对于脓毒症的治疗,目前仅推荐早期血流动力学管理、呼吸复苏以及给予适当的抗生素治疗,尚无被证明有效的额外治疗方案。最初的试验发现人类重组活化蛋白C和drotrecogin @(活化)对脓毒症的生存是有益的,但是未被随后的试验确认,这直接导致了Xigris(dro

JAMA Surg:帕瑞肽 vs氢化可的松用于;胰腺切除术并发症的预防

研究认为,对于预防胰腺手术后并发症,帕瑞肽的效果优于氢化可的松,特别是远端胰腺切除患者

JAMA:氢化可的松对重症新冠肺炎患者器官支持治疗天数的影响

对于需接受ICU治疗的重症新冠肺炎患者,接受氢化可的松治疗可减少患者接受器官支持治疗的天数

JAMA:皮质类固醇可提高COVID-19患者的生存率

皮质类固醇(Corticosteroids)是由肾上腺皮质制造和分泌的类固醇激素,也可经由人工合成。它的药理作用复杂,且广泛涉及生理系统作用,如压力反应、免疫反应,以及发炎、糖类代谢作用、蛋白质分解代

硫胺素、维生素 C 和氢化可的松联合治疗脓毒症和感染性休克

最近的一项研究表明,2017年全球估计有1100万例败血症相关死亡,占总死亡人数的19.7%。在脓毒症患者中经常检测到维生素C和硫胺素的缺乏,据报道,这归因于摄入量减少和代谢需求增加。

Baidu
map
Baidu
map
Baidu
map