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Radiology:3D 超高分辨率US联合微泡对比剂评价兔淋巴结血管结构的价值

2019-06-01 shaosai MedSci原创

背景:对于淋巴结(LN)微循环的改变有助于提示转移。对于转移性LN的识别和定量对预后评价及治疗方案制定是非常有必要的,目前尚缺少一种可靠的非侵入性影像学技术。3D超高分辨率(SR)US对非侵入性显示微血管网具有潜在可能性。

背景:对于淋巴结(LN)微循环的改变有助于提示转移。对于转移性LN的识别和定量对预后评价及治疗方案制定是非常有必要的,目前尚缺少一种可靠的非侵入性影像学技术。3D超高分辨率(SR)US对非侵入性显示微血管网具有潜在可能性。

本研究旨在评价3D SR US成像联合微泡对比剂对兔LN微血管结构和血流显示的可能性。

本研究对两只健康共新西兰白兔进行LN成像。利用线性成像探头进行3D高分辨对比增强US成像。识别微泡表现并进行定位、追踪来形成3D SR图像和超高分辨率流速图。利用声子孔径处理方法提高图像对比并生成增强多普勒和彩色多普勒图像。利用独立样本T检验评价血管大小和血流速。

结果为,SR图像显示兔LN中的微血管,当界定到30μm时小分支可以清晰可见,这要明显短于能量或彩色多普勒的声波长度。在SR图像中明显血管关键大小要小于80μm,这与CT采集数据相一致,然而,利用多普勒技术检出的血管管径要超过80μm。血流速分别显示大部分兔腘窝LN血流速要低于5 mm/sec。

本研究表明,3D 超高分辨率US成像联合微泡对比剂能都以非侵入方法显示并定量淋巴结微血管结构和血流动态图。该技术可作为淋巴结转移的生理学功能研究手段。

原始出处:

Zhu J, Rowland EM, Harput S,et al.3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles.Radiology.DOI:10.1148/radiol.2019182593

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    2019-10-16 lsndxfj
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    2019-06-03 sodoo
  5. [GetPortalCommentsPageByObjectIdResponse(id=2028578, encodeId=45b020285e800, content=<a href='/topic/show?id=1c4e89e6519' target=_blank style='color:#2F92EE;'>#血管结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89765, encryptionId=1c4e89e6519, topicName=血管结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Sat Jun 15 16:53:00 CST 2019, time=2019-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997610, encodeId=14f5199e6101b, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Oct 16 14:53:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936169, encodeId=43d3193616933, content=<a href='/topic/show?id=bf8a10222582' target=_blank style='color:#2F92EE;'>#高分辨率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102225, encryptionId=bf8a10222582, topicName=高分辨率)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIW7uIr5ebYvJohUq0dkkVV05uF9jPpeyCrlcx904mUdMI9UKqpO3bt4GkgYBNdv485qT2NsVE27w/132, createdBy=023c2500122, createdName=ms8543593053280928, createdTime=Fri Nov 15 19:53:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293067, encodeId=5f2d129306e79, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336122, encodeId=949d133612241, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444537, encodeId=76cb144453e60, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614160, encodeId=c9c3161416091, content=<a href='/topic/show?id=35fd506241c' target=_blank style='color:#2F92EE;'>#微泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50624, encryptionId=35fd506241c, topicName=微泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cae519505912, createdName=124987cdm32暂无昵称, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2028578, encodeId=45b020285e800, content=<a href='/topic/show?id=1c4e89e6519' target=_blank style='color:#2F92EE;'>#血管结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89765, encryptionId=1c4e89e6519, topicName=血管结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Sat Jun 15 16:53:00 CST 2019, time=2019-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997610, encodeId=14f5199e6101b, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Oct 16 14:53:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936169, encodeId=43d3193616933, content=<a href='/topic/show?id=bf8a10222582' target=_blank style='color:#2F92EE;'>#高分辨率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102225, encryptionId=bf8a10222582, topicName=高分辨率)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIW7uIr5ebYvJohUq0dkkVV05uF9jPpeyCrlcx904mUdMI9UKqpO3bt4GkgYBNdv485qT2NsVE27w/132, createdBy=023c2500122, createdName=ms8543593053280928, createdTime=Fri Nov 15 19:53:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293067, encodeId=5f2d129306e79, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336122, encodeId=949d133612241, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444537, encodeId=76cb144453e60, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614160, encodeId=c9c3161416091, content=<a href='/topic/show?id=35fd506241c' target=_blank style='color:#2F92EE;'>#微泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50624, encryptionId=35fd506241c, topicName=微泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cae519505912, createdName=124987cdm32暂无昵称, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
    2019-06-03 huagfeg
  7. [GetPortalCommentsPageByObjectIdResponse(id=2028578, encodeId=45b020285e800, content=<a href='/topic/show?id=1c4e89e6519' target=_blank style='color:#2F92EE;'>#血管结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89765, encryptionId=1c4e89e6519, topicName=血管结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Sat Jun 15 16:53:00 CST 2019, time=2019-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997610, encodeId=14f5199e6101b, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Oct 16 14:53:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936169, encodeId=43d3193616933, content=<a href='/topic/show?id=bf8a10222582' target=_blank style='color:#2F92EE;'>#高分辨率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102225, encryptionId=bf8a10222582, topicName=高分辨率)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIW7uIr5ebYvJohUq0dkkVV05uF9jPpeyCrlcx904mUdMI9UKqpO3bt4GkgYBNdv485qT2NsVE27w/132, createdBy=023c2500122, createdName=ms8543593053280928, createdTime=Fri Nov 15 19:53:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293067, encodeId=5f2d129306e79, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336122, encodeId=949d133612241, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444537, encodeId=76cb144453e60, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614160, encodeId=c9c3161416091, content=<a href='/topic/show?id=35fd506241c' target=_blank style='color:#2F92EE;'>#微泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50624, encryptionId=35fd506241c, topicName=微泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cae519505912, createdName=124987cdm32暂无昵称, createdTime=Mon Jun 03 14:53:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]

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