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多囊体生物发生和蛋白质分拣——ESCRT、Vps4、Ubiquitination

2014-01-03 夏恒传,张春霞,冯　凡 生物化学与生物物理学进展

多囊体蛋白质Vps4
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   多囊体(multivesicular body，MVB)是由晚期内吞体的限制膜内陷出芽而形成的动态的亚细胞结构，是真核细胞重要的膜和蛋白质运输与分拣中心，并与信号转导、胞质分裂、基因 沉默、自噬、蛋白质的质量控制、病毒出芽等密切相关．多囊体生物发生涉及20多种囊泡分拣蛋白(Vps)，最重要的是在内吞体膜上形成的4种内吞体运输分 拣复合物(ESCRT 0、Ⅰ、Ⅱ、Ⅲ)

   多囊体(multivesicular body，MVB)是由晚期内吞体的限制膜内陷出芽而形成的动态的亚细胞结构，是真核细胞重要的膜和蛋白质运输与分拣中心，并与信号转导、胞质分裂、基因 沉默、自噬、蛋白质的质量控制、病毒出芽等密切相关．多囊体生物发生涉及20多种囊泡分拣蛋白(Vps)，最重要的是在内吞体膜上形成的4种内吞体运输分 拣复合物(ESCRT 0、Ⅰ、Ⅱ、Ⅲ)和Vps4．ESCRT 0与包涵素在内吞体膜上形成微域并富集泛素化的货物蛋白． ESCRTⅠ和Ⅱ诱导MVB囊泡出芽、促进囊泡形成并分拣货物蛋白到囊泡中． ESCRTⅢ收缩及剪切芽颈，完成最后的膜脱落过程．Vps4解离ESCRT以循环利用． 泛素化及泛素化蛋白也能修饰或调控ESCRT的定位及功能．这些研究表明，泛素化蛋白、ESCRT和Vps4在内吞体膜上的相继协同作用是驱动紧密偶联的 多囊体生物发生及蛋白质分拣的主要力量．本文以蛋白质-蛋白质相互作用为主，综述了ESCRT复合物及Vps4多聚体的组装机制、相互作用、生理功能以及 泛素化蛋白和泛素化对ESCRT的调控，并对下一步研究进行了展望． 多囊体生

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-11-27 ms5353107019656438

    #ubiquitin#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-07-18 yxch36

    #ESCRT#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-09-08 liye789132251

    #Nat#

    0

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    2014-05-03 柳叶一刀

    #白质#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 cmj8wellington

    #蛋白质#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 41514487@qq.com

    #CRT#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1796540, encodeId=2ed81e9654002, content=<a href='/topic/show?id=76a118064d4' target=_blank style='color:#2F92EE;'>#ubiquitin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18064, encryptionId=76a118064d4, topicName=ubiquitin)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Nov 27 16:50:00 CST 2014, time=2014-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785802, encodeId=fb121e858027b, content=<a href='/topic/show?id=4218e0017a' target=_blank style='color:#2F92EE;'>#ESCRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7001, encryptionId=4218e0017a, topicName=ESCRT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 18 05:50:00 CST 2014, time=2014-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879836, encodeId=6f9d18e98366e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 08 03:50:00 CST 2014, time=2014-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765515, encodeId=502a1e65515db, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 03 12:50:00 CST 2014, time=2014-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296882, encodeId=613512968825f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341454, encodeId=0756134145437, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614831, encodeId=03741614831c4, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 12498877m104暂无昵称

    #SCR#

    0

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