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J Rheumatol:附着点炎相关关节炎:儿童和青少年相关葡萄膜炎的患病率和并发症

2020-03-19 xiangting MedSci原创

ERA-U患者的病程通常与成人HLAB27相关性葡萄膜炎相似。然而,一个亚组的患者表现为无症状性葡萄膜炎。

附着点炎相关关节炎(ERA)是幼年特发性关节炎(JIA)的一个亚型,通常伴有前葡萄膜炎。这项研究描述了ERA相关性葡萄膜炎的患病率和特征。

研究人员使用全国小儿风湿病数据库(NPRD)的横断面数据来表征ERA相关性葡萄膜炎(ERA-U)。除了社会人口学指标外,研究还记录了葡萄膜炎的发生和病程,其中包括症状、视力和并发症,以及JIA特征例如疾病活动性(cJADAS10)、功能能力(CHAQ评分)、实验室指标和治疗。

2002年至2014年,NPRD记录的24841例JIA患者中有3778例(15.2%)患有ERA,其中280例(7.4%)出现葡萄膜炎。这些患者中的22.9%有可用的葡萄膜炎附加模块详细眼科记录。63%的患者出现葡萄膜炎急性症状。葡萄膜炎患者中男性、HLA-B27阳性较常见且ERA发病年龄较小,并且在首次葡萄膜炎记录中,其ESR值高于无葡萄膜炎患者。葡萄膜炎诊断时的平均年龄为11.5(±3.9)岁(50%在ERA发病后两年内出现)。使用皮质类固醇以及合成和生物疾病改善抗风湿药物进行全身治疗与患葡萄膜炎的风险降低相关(但没有显著性)。

ERA-U患者的病程通常与成人HLAB27相关性葡萄膜炎相似。然而,一个亚组的患者表现为无症状性葡萄膜炎。

原始出处:

Karoline Walscheid. Enthesitis-related arthritis: prevalence and complications of associated uveitis in children and adolescents from a population-based nation-wide study in Germany. J Rheumatol. March 2020.

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    2020-07-08 丁鹏鹏
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2038257, encodeId=65e9203825e04, content=<a href='/topic/show?id=749f9e97583' target=_blank style='color:#2F92EE;'>#附着点炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97975, encryptionId=749f9e97583, topicName=附着点炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Mon Sep 21 12:18:35 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818597, encodeId=ac7d181859e94, content=<a href='/topic/show?id=82e09e9769c' target=_blank style='color:#2F92EE;'>#附着点炎相关关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97976, encryptionId=82e09e9769c, topicName=附着点炎相关关节炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Thu Jul 16 10:18:35 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937508, encodeId=c211193e508e6, content=<a href='/topic/show?id=b3252822854' target=_blank style='color:#2F92EE;'>#儿童和青少年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28228, encryptionId=b3252822854, topicName=儿童和青少年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Oct 24 00:18:35 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758222, encodeId=a2871e58222b0, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Jul 08 00:18:35 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250676, encodeId=449312506e6c2, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Mar 21 05:18:35 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266132, encodeId=4ad81266132c1, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Mar 21 05:18:35 CST 2020, time=2020-03-21, status=1, ipAttribution=)]
    2020-03-21 lmm397
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