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Neurology:帕金森病人接受睡眠状态下脑深部电刺激有益于病情缓解

2017-10-11 zhangfan MedSci原创

研究认为,对于帕金森患者进行睡眠状态下的脑深部电刺激更有利于患者6个月的运动功能改善

近日研究人员比较了帕金森患者睡眠与清醒状态下脑深部电刺激(DBS)治疗后6个月的运动和非运动结果差异。

研究在俄勒冈州开展,患者接受的电刺激治疗以电极成像结果作为指导。治疗6个月后,医生对患者疾病情况进行评估,评估内容包括左旋多巴"开关"现象、帕金森病统一评分(UPDRS)II和III,39项帕金森病问卷、运动情况和言语流畅性。

30名患者接受睡眠DBS,39人接受清醒DBS。研究结果显示,组间UPDRS III或UPDRS II评分未见显著差异 (UPDRS III :+14.8 ± 8.9 vs +17.6 ± 12.3, p = 0.19;UPDRS II :+9.3 ± 2.7 vs +7.4 ± 5.8, p = 0.16)。睡眠刺激组患者"开关"现象以及无障碍运动情况优于清醒状态组 (+6.4 ± 3.0 h/d vs +1.7 ± 1.2 h/d, p = 0.002)。两组生活质量评分显著提高(清醒组得分+18.8 ± 9.4;睡眠组得分+8.9 ± 11.5)。睡眠组综合指标改善(P = 0.004)、认知(P = 0.011)和沟通(P<0.001)单项分数均优于清醒组。睡眠组患者言语流畅性更高,主要体现在类别以及音位流畅性方面。

研究认为,对于帕金森患者进行睡眠状态下的脑深部电刺激更有利于患者6个月的运动功能改善。

原始出处:


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    2018-05-28 yinhl1978
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    2017-10-27 虈亣靌

    内容丰富.值得学习

    0

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    2017-10-14 虈亣靌

    不错的.学习了.谢谢分享!

    0

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    2017-10-11 137****9095

    henhao

    0

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    2017-10-11 Y—xianghai

    学习了新知识

    0

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