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JCEM:绝经后女性体内内源性性激素与脂肪因子、胃饥饿素的关联研究

2014-11-23 MedSci MedSci原创

研究背景: 有研究提示性激素、脂肪因子及胃饥饿素在控制食欲、能量平衡、维持脂肪量和炎症等方面处于中心位置。女性在绝经后有体重增加的趋势,并且脂肪组织是绝经后主要的性激素来源。而女性绝经后患心血管疾病的风险显著增加,所以理解这些物质的动态变化具有重要意义。 研究目的: 评估绝经后女性体内脂肪因子及胃饥饿素与性激素水平的相关性。 研究设计: 交叉横断面研究。 研究依

研究背景:

有研究提示性激素、脂肪因子及胃饥饿素在控制食欲、能量平衡、维持脂肪量和炎症等方面处于中心位置。女性在绝经后有体重增加的趋势,并且脂肪组织是绝经后主要的性激素来源。而女性绝经后患心血管疾病的风险显著增加,所以理解这些物质的动态变化具有重要意义。

研究目的:

评估绝经后女性体内脂肪因子及胃饥饿素与性激素水平的相关性。

研究设计:

交叉横断面研究。

研究依托:

动脉粥样硬化研究中心。

受试者:

我们收集了一项正在实施的临床研究——雌激素早期及晚期干预试验(ELITE)中的634名绝经后女性的基线资料。纳入的受试者需要符合过去五年内没有慢性疾病史,并且未实行外源性激素治疗等标准。

主要结局指标:

血清中雌酮(E1)、总雌二醇(E2)、游离雌二醇(FE2)、游离睾酮(FT)、总睾酮(T)和性激素结合球蛋白(SHBG)。

研究结果:

在校正了年龄、种族、绝经时间和BMI等因素后,瘦素水平与E1E2FE2FT呈显著正相关,而与SHBG水平呈负相关。在控制了BMI的影响后,仅有脂联素与FE2的负相关关系及其与SHBG的正相关关系仍然有统计学意义,即脂联素与E1E2FT的负相关关系实质上受BMI介导的。胃饥饿素与E1E2FE2SHBG的相关性不独立于BMI存在。腰臀比不参与影响上述任一种相关关系。

研究结论:

在绝经后女性人群中,瘦素及脂联素的浓度是大体上与性激素及SHBG水平相关,而与肥胖情况无关。

原始出处:

Roksana Karim, Frank Z. Stanczyk, Roberta D. Brinton, Jamaica Rettberg, Howard N. Hodis, and Wendy J. Mack. Association of Endogenous Sex Hormones with Adipokines and Ghrelin in Postmenopausal Women. JCEM, Nov 18, 2014.

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    2015-08-23 smallant2015
  3. 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    2015-06-08 ljjj1053

    好好学习学习

    0

  4. 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createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 23 20:04:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26396, encodeId=a26826396db, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:37:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045606, encodeId=9d582045606ef, content=<a href='/topic/show?id=76fb8433919' target=_blank style='color:#2F92EE;'>#脂肪因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84339, encryptionId=76fb8433919, topicName=脂肪因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Jun 09 14:04:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062878, encodeId=0ae220628e82f, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Oct 03 20:04:00 CST 2015, time=2015-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682010, encodeId=289316820100a, content=<a href='/topic/show?id=15593040e9a' target=_blank style='color:#2F92EE;'>#内源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30407, encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Wed Jan 07 09:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257007, encodeId=ae1e125e00779, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286352, encodeId=a218128635239, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454727, encodeId=9e6a1454e274d, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526604, encodeId=a84f152660460, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=)]
    2015-06-09 zutt
  5. [GetPortalCommentsPageByObjectIdResponse(id=1993835, encodeId=4b8f199383540, content=<a href='/topic/show?id=3c0a8342075' target=_blank style='color:#2F92EE;'>#胃饥饿素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83420, encryptionId=3c0a8342075, topicName=胃饥饿素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Jan 07 14:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777497, encodeId=bee51e7749789, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 23 20:04:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26396, encodeId=a26826396db, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:37:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045606, encodeId=9d582045606ef, content=<a href='/topic/show?id=76fb8433919' target=_blank style='color:#2F92EE;'>#脂肪因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84339, encryptionId=76fb8433919, topicName=脂肪因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Jun 09 14:04:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062878, encodeId=0ae220628e82f, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Oct 03 20:04:00 CST 2015, time=2015-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682010, encodeId=289316820100a, content=<a href='/topic/show?id=15593040e9a' target=_blank style='color:#2F92EE;'>#内源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30407, encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Wed Jan 07 09:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257007, encodeId=ae1e125e00779, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286352, encodeId=a218128635239, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454727, encodeId=9e6a1454e274d, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526604, encodeId=a84f152660460, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=)]
    2015-10-03 achengzhao
  6. [GetPortalCommentsPageByObjectIdResponse(id=1993835, encodeId=4b8f199383540, content=<a href='/topic/show?id=3c0a8342075' target=_blank style='color:#2F92EE;'>#胃饥饿素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83420, encryptionId=3c0a8342075, topicName=胃饥饿素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Jan 07 14:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777497, encodeId=bee51e7749789, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 23 20:04:00 CST 2015, time=2015-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26396, encodeId=a26826396db, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:37:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045606, encodeId=9d582045606ef, content=<a href='/topic/show?id=76fb8433919' target=_blank style='color:#2F92EE;'>#脂肪因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84339, encryptionId=76fb8433919, topicName=脂肪因子)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Wed Jan 07 09:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257007, encodeId=ae1e125e00779, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286352, encodeId=a218128635239, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454727, encodeId=9e6a1454e274d, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Tue Nov 25 04:04:00 CST 2014, time=2014-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526604, encodeId=a84f152660460, content=<a 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1993835, encodeId=4b8f199383540, content=<a href='/topic/show?id=3c0a8342075' target=_blank style='color:#2F92EE;'>#胃饥饿素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83420, encryptionId=3c0a8342075, topicName=胃饥饿素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Jan 07 14:04:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777497, encodeId=bee51e7749789, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  8. 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  9. 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