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Clin Transl Allergy:屋尘螨皮下免疫治疗在老年过敏性鼻炎患者中的疗效和安全性证据

2017-12-20 AlexYang MedSci原创

过敏原特异性免疫疗法(AIT)在老年病人中是具有争议的,并且到目前为止在该人群中能够支持该种疗法安全性和疗效方面的证据依据很少。最近,有研究人员评估了屋尘螨过敏原AIT疗法在年龄大于65岁且患有过敏性鼻炎(AR)和对屋尘螨过敏的患者中的疗效和安全性。研究包括了58名只对屋尘螨敏感的老年病人,并且被随机分配到数目匹配的两个平行小组中,并且进行了如下的干预:利用PURETHAL螨虫或者安慰剂进行为期2

过敏原特异性免疫疗法(AIT)在老年病人中是具有争议的,并且到目前为止在该人群中能够支持该种疗法安全性和疗效方面的证据依据很少。最近,有研究人员评估了屋尘螨过敏原AIT疗法在年龄大于65岁且患有过敏性鼻炎(AR)和对屋尘螨过敏的患者中的疗效和安全性。

研究包括了58名只对屋尘螨敏感的老年病人,并且被随机分配到数目匹配的两个平行小组中,并且进行了如下的干预:利用PURETHAL螨虫或者安慰剂进行为期2年的不间断AIT治疗。并利用AAdSS和TCRS对症状和药物治疗得分进行评估,并依据鼻炎生活质量调查问卷(RQLQ)、鼻过敏原刺激响应性、对D. pteronyssinus 、D. farinae 、Der p1Der p2的血清特异性过敏原lgG4对生活质量进行了评估。另外,研究人员还分析了意向治疗群体。

研究发现,经过24个月的AIT治疗,AAdSS从 4.27 ± 1.58显著的降低到了1.82 ± 0.71(p<0.05)。TCRS在2年的AIT治疗后具有显著性的降低。对D. pteronyssinus 、D. farinae 、Der p1 Der p2血清特异性LgG4在AIT试验期间表现为增加。RQLQ得分在接受AIT的病人中具有显著的改善,从1.86(95% CI 1.51-1.78)降低到了1.26(95% CI 1.09-1.55)。另外,在AIT治疗期间出现了2例轻度的系统性过敏反应(程度1)。最后,研究人员指出,DBPC试验表明了AIT在患有老年过敏性鼻炎病人中,对屋尘螨过敏原的治疗是有效的和安全的。

原始出处:


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    2018-04-05 bsmagic9140
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  5. 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encodeId=778e13485812f, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Dec 22 12:53:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271133, encodeId=8d0a2e1133e2, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Dec 21 08:48:23 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271048, encodeId=21122e1048a4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Thu Dec 21 00:33:57 CST 2017, time=2017-12-21, status=1, ipAttribution=)]
    2017-12-22 膀胱癌
  6. 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  7. 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CST 2017, time=2017-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271125, encodeId=d8af2e1125c0, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Dec 21 08:07:56 CST 2017, time=2017-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271114, encodeId=4da62e111497, content=好好学习.天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Dec 21 07:54:38 CST 2017, time=2017-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271048, encodeId=21122e1048a4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Thu Dec 21 00:33:57 CST 2017, time=2017-12-21, status=1, ipAttribution=)]
    2017-12-21 139****5926

    好好文章学习了

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271048, encodeId=21122e1048a4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Thu Dec 21 00:33:57 CST 2017, time=2017-12-21, status=1, ipAttribution=)]
    2017-12-21 明月清辉

    谢谢分享.学习了

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271048, encodeId=21122e1048a4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Thu Dec 21 00:33:57 CST 2017, time=2017-12-21, status=1, ipAttribution=)]
    2017-12-21 忠诚向上

    好好学习.天天向上

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271048, encodeId=21122e1048a4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Thu Dec 21 00:33:57 CST 2017, time=2017-12-21, status=1, ipAttribution=)]
    2017-12-21 sunsmile 2017

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