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Cell Chem Biol:新一代前列腺癌药物之间的相似之处

2017-06-23 Heather_z727 来宝网

近日,发表于《细胞化学生物学》上的文章为前列腺的治疗奠定了基础,在此次研究中,科学家首次阐述了新一代前列腺癌药物在体内的运作机制,并如何根据代谢来决定肿瘤的活性。

近日,发表于《细胞化学生物学》上的文章为前列腺的治疗奠定了基础,在此次研究中,科学家首次阐述了新一代前列腺癌药物在体内的运作机制,并如何根据代谢来决定肿瘤的活性。

前列腺癌的新一代药物通过切断前列腺肿瘤雄激素的供应,来对抗雄性激素,燃料前列腺癌症。不幸的是,前列腺肿瘤最终会对这些药物产生耐药性,这也就突出了新疗法的必要性。

研究人员表示:“在过去的十年里,前列腺癌是男性癌症的第二大死亡原因,很多癌症患者已经尝试过所有的疗法,但是效果并不理想。我们的目标是改善这些现有药物的使用和作用,希望新设计的疗法可以更好,更长效的为患者服务。”

在此次试验中,克利夫兰诊所的研究人员针对Galeterone进行研究,这是一种甾类抗雄激素药物,癌症生物学表明Galeterone代谢的时候,就会转换为中介D4G分子,阻断雄激素合成,降低可用于癌细胞雄激素的数量。但是,Galeterone的陷阱是,它可能刺激肿瘤,转化为另一个分子。

除此之外,研究人员发现另一个甾体药物阿比特龙,也有类似的问题。阿比特龙是具有里程碑意义的研究,阿比特龙的抗肿瘤活性代谢物D4A大于其他,如果药物稍作调整,一定可以更好地提高疗效。

原始出处:

Mohammad Alyamani, Zhenfei Li, et al. Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities. Cell Chemical Biology Published: June 22, 2017

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    2018-04-06 维他命
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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 20 13:06:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215382, encodeId=fd3721538297, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Jun 25 23:56:45 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214877, encodeId=37cf2148e702, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=078f1661649, createdName=wei834766788, createdTime=Sat Jun 24 08:38:00 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214534, encodeId=73c921453450, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jun 24 00:02:35 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214492, encodeId=c20e21449280, content=不错,学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:34:43 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-12-20 sunylz
  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:34:43 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-25 luominglian113

    学习了,谢谢分享

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:34:43 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-24 虈亣靌

    不错的,学习了,谢谢分享!

    0

  7. 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    2017-06-24 清风拂面

    很好的文章,学习了

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:34:43 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-24 wei834766788

    学习了!!!!!!

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:34:43 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-24 doctorJiangchao

    继续学习。

    0

  10. 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    2017-06-23 林3301

    不错,学习下

    0

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德克萨斯大学奥斯汀分校的研究人员发现了一种有潜力的天然化合物,这种化合物可以成功“饿死”前列腺癌癌细胞,使肿瘤缩小。这种化合物存在于姜黄,红葡萄皮和苹果皮中,如果将这三者组合,效果似乎更加强大。完整的研究报告发表于《精密肿瘤学》杂志上。

Brit J Cancer:肿瘤异质性给癌症生物标记研究带来了巨大挑战

癌症的高度基因组多样性表明了鉴定目标预后标记的巨大挑战。最近,有研究人员调查了重力异质性的程度以及对选择的预后标记的评估的影响,并且以前列腺癌作为模型进行研究。研究人员在赖在304名病人的根治性前列腺切除术标本(RP)中,评估了格林森得分(GS)、DNA倍体状态和磷酸化以及张力蛋白同系物(PTEN)的表达,这些病人跟踪调查时间的中值为10年(范围为6-12年)。研究人员对每一个肿瘤块进行了GS评估

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在前列腺癌发展到去势抵抗性(CRPC)阶段的过程中,雄激素受体(AR)发挥着关键作用。雄激素受体抑制剂不能抑制AR或它的剪接异构体AR-V7的表达,因而没有治疗效果。本研究报道,在AR转录起始位点的上游,酪氨酸激酶ACK1(TNK2)在酪氨酸88上磷酸化组蛋白H4。WDR5/MLL2复合物读取H4-Y88磷酸化标记并沉淀转录性活化H3K4-三甲基标记,从而促进AR转录。以ACK1抑制剂(R)-9b

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