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Stroke:慢性肾脏病是卒中患者血管周间隙增大的危险因素

2020-10-10 MedSci原创 MedSci原创

在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。

血管周间隙增大(EPVS)被认为是小血管疾病的亚临床标志物,与卒中和痴呆的风险增加相关。越来越多的证据将慢性肾脏疾病(CKD)与小血管疾病联系起来。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在探讨CKD和EPVS负担之间的关系以及人种对这种关系的影响。

连续就诊的接受脑磁共振成像检查的卒中患者(n=894)被纳入研究。人种分为白人、黑人或其他(其他人种)。CKD定义为肾小球滤过率<60 mL/min/1.73m2持续3个月以上。按照标准法对EPVS进行评级,将其二分进行分析(轻度[<20] vs. 重度[≥20]),并按脑部区域(基底神经节和半卵圆中央)进行分层。

在多变量校正分析中,CKD与严重EPVS的关联因人种而异。比较不同人种伴有或不伴有CKD的患者,研究人员发现CKD白人发生严重半卵圆中央EPVS的几率更高(比值比[OR]为2.41[95%CI为0.98-5.88])。在CKD患者中,与白人(分别有OR为1.93 [95%CI为1.13-3.16]和OR为1.90 [95%CI为1.16-3.11])和其他人种(分别有OR为2.03 [95%CI为1.23-3.36]和OR为2.02 [95%CI为1.22-3.34])相比,黑人患者在基底神经节和半卵圆中央区域发生严重EPVS的几率更高。

由此可见,在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。

原始出处:

Ashley A. Penton,et al.Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028688

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1720353, encodeId=2d5e1e2035323, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Oct 14 23:33:13 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891781, encodeId=d4ee891e8184, content=在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Oct 13 15:05:10 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616208, encodeId=76731616208bf, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Oct 12 01:33:13 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026698, encodeId=7ffe102669867, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Oct 10 13:33:13 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1720353, encodeId=2d5e1e2035323, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Oct 14 23:33:13 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891781, encodeId=d4ee891e8184, content=在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Oct 13 15:05:10 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616208, encodeId=76731616208bf, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Oct 12 01:33:13 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026698, encodeId=7ffe102669867, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Oct 10 13:33:13 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
    2020-10-13 咻凡

    在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1720353, encodeId=2d5e1e2035323, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Oct 14 23:33:13 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891781, encodeId=d4ee891e8184, content=在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Oct 13 15:05:10 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616208, encodeId=76731616208bf, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Oct 12 01:33:13 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026698, encodeId=7ffe102669867, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Oct 10 13:33:13 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1720353, encodeId=2d5e1e2035323, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Oct 14 23:33:13 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891781, encodeId=d4ee891e8184, content=在半卵圆中央区域有严重EPVS的卒中患者中CKD更为普遍。当按人种和大脑区域进行分层时,这种关系有所不同。需要进一步的研究以确认CKD与小血管疾病的亚临床指标之间的关系可能根据人种而有所不同。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Oct 13 15:05:10 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616208, encodeId=76731616208bf, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Oct 12 01:33:13 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026698, encodeId=7ffe102669867, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Oct 10 13:33:13 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
    2020-10-10 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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