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Sci Rep:ABO血型不融合肾移植肾移植中选择性血浆置换研究

2020-02-09 AlexYang MedSci原创

自从2015年,有研究人员在ABO血型不融合肾移植前就进行了选择性血浆置换(SePE)进行分离性输血。最近,有研究人员将SePE分成2个小组,即只使用白蛋白组(组A)和部分的使用新鲜冷冻血浆组(组F),并并比较了两组之间的临床效果。研究总共包括了58次SePE(组A:n=41,组F:n=17),并且是在30名ABOi肾移植受试者中进行的。研究人员对异凝集素效价减少、血清IgG和IgM水平的变化以及

自从2015年,有研究人员在ABO血型不融合肾移植前就进行了选择性血浆置换(SePE)进行分离性输血。最近,有研究人员将SePE分成2个小组,即只使用白蛋白组(组A)和部分的使用新鲜冷冻血浆组(组F),并并比较了两组之间的临床效果。

研究总共包括了58次SePE(组A:n=41,组F:n=17),并且是在30名ABOi肾移植受试者中进行的。研究人员对异凝集素效价减少、血清IgG和IgM水平的变化以及凝血因子(纤维蛋白原、XIII因子)和副作用的发生率进行了回顾性的比较。研究发现,与组A相比,组F的异凝集素效价减少更加显著。免疫球蛋白和凝血因子在组F中得到了充分的补充。同时,副作用的发生率在组F中显著更高。另外,不考虑许多的副作用情况下,使用FFP(能够有效的减少异凝集素滴度,补充免疫球蛋白和凝血因子)的SePE可能是在ABO不融合肾移植前分离性输血的一种有益的治疗方式。

原始出处:


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    2020-07-07 yxch48
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
    2020-02-11 licz0427
  7. [GetPortalCommentsPageByObjectIdResponse(id=1742674, encodeId=b4811e42674af, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Jul 07 01:09:00 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984286, encodeId=fba41984286a3, content=<a href='/topic/show?id=a35789001cc' target=_blank style='color:#2F92EE;'>#血型不融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89001, encryptionId=a35789001cc, topicName=血型不融合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Sat Oct 31 13:09:00 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922948, encodeId=e7021922948a7, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Tue May 19 08:09:00 CST 2020, time=2020-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379330, encodeId=267813e9330c0, content=<a href='/topic/show?id=d4121e66e8' target=_blank style='color:#2F92EE;'>#ABO血型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1766, encryptionId=d4121e66e8, topicName=ABO血型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485788, encodeId=e7f21485e88f3, content=<a href='/topic/show?id=e75889215f7' target=_blank style='color:#2F92EE;'>#血浆置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89215, encryptionId=e75889215f7, topicName=血浆置换)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed838051612, createdName=12498e8em74暂无昵称, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525529, encodeId=98d5152552932, content=<a href='/topic/show?id=08548885835' target=_blank style='color:#2F92EE;'>#融合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88858, encryptionId=08548885835, topicName=融合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08a911636812, createdName=licz0427, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598046, encodeId=bfc115980466e, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Feb 11 03:09:00 CST 2020, time=2020-02-11, status=1, ipAttribution=)]
    2020-02-11 闆锋旦

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近来,环状RNA (circRNAs)因为其能够调控基因表达成为新的调控因子。在急性肾损伤患者的血液中可以检测到circRNAs。我们测试了尿液中是否存在环状RNA,以及能否作为急性排斥肾移植患者预后的新的预测因子。

肾移植围手术期处理操作规范(2019版)

为了进一步规范肾移植围手术期处理操作技术,中华医学会器官移植学分会组织器官移植学专家从肾移植术后一般监护与处理,受者液体管理与相关并发症的处理,受者电解质、酸碱代谢管理等方面,制订肾移植围手术期处理操作技术规范。

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