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Blood:危重儿童无症状中心静脉导管相关性血栓形成可不进行抗凝治疗

2018-11-02 MedSci MedSci原创

中心点:在189名儿童中,31位儿童存在无症状的中心静脉导管(CVC)相关性血栓,但尽管未进行治疗,仅一名儿童出现轻度的长期后遗症。紧急股动脉CVC置入术可预测2年内的残余血栓形成(p=0.02),并与急性加重和并发症相关。摘要:儿童无症状中心静脉导管(CVC)相关性血栓形成的发生率浮动在5-69%。对于无症状CVC相关性血栓形成导致的急性和长期并发症的发生率,如置管后血栓性综合征(PTS),尚无

中心点:

在189名儿童中,31位儿童存在无症状的中心静脉导管(CVC)相关性血栓,但尽管未进行治疗,仅一名儿童出现轻度的长期后遗症。

紧急股动脉CVC置入术可预测2年内的残余血栓形成(p=0.02),并与急性加重和并发症相关。

摘要:

儿童无症状中心静脉导管(CVC)相关性血栓形成的发生率浮动在5-69%。对于无症状CVC相关性血栓形成导致的急性和长期并发症的发生率,如置管后血栓性综合征(PTS),尚无确切数据。

Sophie Jones等人开展一前瞻性研究,对儿科重症监护室的189位儿童的预后进行研究,目的是评估住院期间无症状CVC相关性血栓形成的发生率,以及残余CVC相关性血栓形成和之后2年内PTS的发生率。同时鉴定CVC相关性血栓形成的风险因素。本研究内的儿童均未针对无症状中心静脉导管(CVC)相关性血栓进行治疗。

对146名儿童进行超声检查,急性CVC相关性血栓形成的发生率为21.9%。两位儿童出现血栓症状。对126名儿童进行随访评估,无放射学血栓扩张或临床栓塞。采用两种公认的PTS量表,有两名儿童出现临床显着的PTS(一位有症状,一位无症状CVC相关性血栓形成),但均无功能性损伤。

心脏骤停是住院期间CVC相关性血栓形成的危险因素,股静脉CVC置管位置可预测两年内残余血栓形成。

本研究结果显示无症状CVC相关性血栓形成不进行治疗的急性和长期并发症的发生率均很低,挑战了危重儿童无症状CVC相关性血栓形成需要进行抗凝治疗的观点。


原始出处:

Sophie Jones,et al. The natural history of asymptomatic central venous catheter-related thrombosis in critically ill children. Blood  2018  :blood-2018-05-849737;  doi: https://doi.org/10.1182/blood-2018-05-849737

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    2019-09-01 fusion
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    2018-11-03 易水河

    学习学习很好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1697794, encodeId=83a3169e794c1, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Sep 01 21:15:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837591, encodeId=f0ed183e59185, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat May 11 08:15:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796988, encodeId=f8e31e96988a3, content=<a href='/topic/show?id=5a6e221853a' target=_blank style='color:#2F92EE;'>#中心静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22185, encryptionId=5a6e221853a, topicName=中心静脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Dec 29 05:15:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365547, encodeId=13d2136554e6b, content=<a href='/topic/show?id=e2ff2218823' target=_blank style='color:#2F92EE;'>#中心静脉导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22188, encryptionId=e2ff2218823, topicName=中心静脉导管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Sun Nov 04 12:15:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485017, encodeId=ca41148501ee6, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Sun Nov 04 12:15:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351367, encodeId=d6b535136e6b, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Nov 03 10:24:34 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351318, encodeId=0f1c3513187e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Fri Nov 02 23:15:48 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351305, encodeId=80913513056b, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 02 21:34:42 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-02 医者仁心5538

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1697794, encodeId=83a3169e794c1, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Sep 01 21:15:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837591, encodeId=f0ed183e59185, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat May 11 08:15:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796988, encodeId=f8e31e96988a3, content=<a href='/topic/show?id=5a6e221853a' target=_blank style='color:#2F92EE;'>#中心静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22185, encryptionId=5a6e221853a, topicName=中心静脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Dec 29 05:15:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365547, encodeId=13d2136554e6b, content=<a href='/topic/show?id=e2ff2218823' target=_blank style='color:#2F92EE;'>#中心静脉导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22188, encryptionId=e2ff2218823, topicName=中心静脉导管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Sun Nov 04 12:15:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485017, encodeId=ca41148501ee6, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Sun Nov 04 12:15:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351367, encodeId=d6b535136e6b, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Nov 03 10:24:34 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351318, encodeId=0f1c3513187e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Fri Nov 02 23:15:48 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351305, encodeId=80913513056b, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 02 21:34:42 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-02 天地飞扬

    了解一下,谢谢分享!

    0

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