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部分预烧结对介孔生物活性玻璃机械性能的影响

2018-01-22 MedSci MedSci原创

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由45S5Bioglass®陶瓷（BG）制成的支架由于其优异的生物活性和与天然骨组织结合的能力而在骨再生领域中的显示出巨大的临床应用潜力。然而，多孔BG支架因其机械性能和烧结时产生明显的体积收缩而受到应用限制。本研究旨在通过立体光刻（SLA）方法制造具有规则和相互连接的孔隙网络，并使用各种计算机辅助设计架构的机械强度和多孔Bioglass®陶瓷支架。结果显示，钻石（DM）样的结构为支架提供了可控的

由45S5Bioglass®陶瓷（BG）制成的支架由于其优异的生物活性和与天然骨组织结合的能力而在骨再生领域中的显示出巨大的临床应用潜力。然而，多孔BG支架因其机械性能和烧结时产生明显的体积收缩而受到应用限制。本研究旨在通过立体光刻（SLA）方法制造具有规则和相互连接的孔隙网络，并使用各种计算机辅助设计架构的机械强度和多孔Bioglass®陶瓷支架。

结果显示，钻石（DM）样的结构为支架提供了可控的结果，且烧结过程中并没有任何可观察的封闭孔隙。当相同孔隙率（〜60vol％）的DM支架的孔尺寸从700μm减小到400μm时，抗压强度值从3.5MPa增加到6.7MPa。另外，与标准45S5Bioglass®相比，采用部分预烧结生物玻璃可以获得更小的尺寸收缩。来自预烧结生物玻璃的支架也表现出稍微改善的抗压强度。

原始出处：

Thavornyutikarn B, Tesavibul P, et al., Porous 45S5 Bioglass®-based scaffolds using stereolithography: Effect of partial pre-sintering on structural and mechanical properties of scaffolds. Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:1281-1288. doi: 10.1016/j.msec.2017.03.001. Epub 2017 Mar 2.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2005173, encodeId=856420051e393, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed Mar 28 04:48:00 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664831, encodeId=11ca166483140, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Tue Oct 16 22:48:00 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284914, encodeId=825028491405, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 04 06:38:10 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281219, encodeId=2ba628121930, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jan 23 09:01:10 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281104, encodeId=9e21281104b5, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Jan 23 00:30:22 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281099, encodeId=260a281099ab, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Tue Jan 23 00:24:14 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-03-28 fyxzlh

    #生物活性玻璃#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2005173, encodeId=856420051e393, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed Mar 28 04:48:00 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664831, encodeId=11ca166483140, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Tue Oct 16 22:48:00 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284914, encodeId=825028491405, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 04 06:38:10 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281219, encodeId=2ba628121930, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jan 23 09:01:10 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281104, encodeId=9e21281104b5, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Jan 23 00:30:22 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281099, encodeId=260a281099ab, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Tue Jan 23 00:24:14 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-10-16 luckyshitiancai_42705692

    #介孔#

    0

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    2018-02-04 1e207054m17(暂无匿称)

    非常好.谢谢分享

    0

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    2018-01-23 明月清辉

    谢谢分享.学习了

    0

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    2018-01-23 飛歌

    厉害了我的哥

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2005173, encodeId=856420051e393, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed Mar 28 04:48:00 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664831, encodeId=11ca166483140, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Tue Oct 16 22:48:00 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284914, encodeId=825028491405, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 04 06:38:10 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281219, encodeId=2ba628121930, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jan 23 09:01:10 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281104, encodeId=9e21281104b5, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Jan 23 00:30:22 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281099, encodeId=260a281099ab, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Tue Jan 23 00:24:14 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 情途末路

    学习了.获益匪浅!感谢分享

    0

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