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Clinical Translational Gastroenterology: II型糖尿病患者中性别差异对大肠癌风险的影响

2019-12-11 不详 MedSci原创

结直肠癌(CRC)对II型糖尿病(T2DM)患者构成了生命挑战。本项研究探究了T2DM患者的CRC发生的危险因素。

背景及目的:
直肠癌(CRC)对II型糖尿病(T2DM)患者构成了生命挑战。本项研究探究了T2DM患者的CRC发生的危险因素。

方法:
研究人员回顾性地从国民健康保险公司数据库中收集数据,该数据约占韩国人口的97%。肥胖是通过体重指数(BMI)定义的;根据腰围定义腹部肥胖。其他变量是使用人口统计学,人体测量学和实验室数据进行定义。

结果:
本项研究总共分析了2591149例T2DM患者。在随访期间(中位数为5.4年),发现了24236例CRC病例。年龄(≥70岁),男性,吸烟,饮酒,高血压以及使用胰岛素和/或磺酰脲类是CRC的重要危险因素。在男性中,吸烟和饮酒更容易导致CRC,而BMI升高是女性的重要危险因素。与体重正常和腰围正常的患者相比,BMI≥25 kg/m2且腹部肥胖的女性患CRC的风险增加18%(危险比=1.184,95%的置信区间1.123-1.25),而男性BMI≥25 kg / m2的患者腹部肥胖和腹部肥胖的患病风险增加8%(危险比= 1.087,95%置信区间1.049–1.127)。

讨论:
患者的CRC危险因素因性别而异。吸烟和大量饮酒是男性患CRC的风险。BMI≥25 kg / m 2且腹部肥胖的女性患者发生CRC的风险高于男性。

原始出处:
Lee, Ji Min. et al. Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus. Clinical Translational Gastroenterology.2019.

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    2020-02-29 bsmagic9140
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createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Feb 29 08:07:00 CST 2020, time=2020-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795891, encodeId=e21f1e9589126, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Sat Jan 25 17:07:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712220, encodeId=16771e1222088, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Feb 22 18:07:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072810, encodeId=3e6220e2810e0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Jul 31 02:07:00 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796015, encodeId=4df31e9601597, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Sun Oct 18 03:07:00 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067481, encodeId=5fec206e48193, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9592, encryptionId=9a8d9592b0, topicName=II型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d7914226234, createdName=lsj629, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474857, encodeId=852a14e485716, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2064917, encodeId=6705206491e94, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 09 12:07:00 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657271, encodeId=d89b165e27180, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Feb 29 08:07:00 CST 2020, time=2020-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795891, encodeId=e21f1e9589126, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Sat Jan 25 17:07:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712220, encodeId=16771e1222088, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Feb 22 18:07:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072810, encodeId=3e6220e2810e0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Jul 31 02:07:00 CST 2020, time=2020-07-31, status=1, ipAttribution=), 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channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9592, encryptionId=9a8d9592b0, topicName=II型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d7914226234, createdName=lsj629, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474857, encodeId=852a14e485716, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
    2020-07-31 许安
  6. 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  7. 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  8. 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channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9592, encryptionId=9a8d9592b0, topicName=II型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d7914226234, createdName=lsj629, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474857, encodeId=852a14e485716, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Dec 13 03:07:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
    2020-08-02 sjq027
  9. 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  10. 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BMC Gastroenterology:不同阶段大肠癌不同病理亚型的预后分析

目前学界尚不清楚不同阶段大肠癌的不同病理亚型的患者预后是否有明确差异。因此,本项研究旨在探究其中的关系。

BMJ Open Gastroenterology: 肥胖是非酒精性脂肪肝疾病、胃癌和大肠癌的独立预测因素

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J Gastroenterology:Barrett食管与结肠癌之间的关系

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Clinical Translational Gastroenterology:二甲双胍与糖尿病患者患大肠癌几率降低相关

二甲双胍可能与降低结直肠癌(CRC)的风险有关,但以前的研究结果存在矛盾,并且样本量不足以检查该关联是否因解剖部位而异。因此,本项研究探究了在接受结肠镜检查的大量糖尿病患者中,二甲双胍是否与降低的CRC风险有关。

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