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J Gastroenterol Hepatol:HBV核心相关抗原水平能够预测乙肝病毒携带者的肝硬化进展

2017-11-27 MedSci MedSci原创

HBcrAg水平增加,增加了疾病进展到肝硬化程度的风险。HBcrAg是肝硬化发展的良好预测指标。

研究背景:一些HBV标志物被认定为是慢性HBV感染疾病进展到肝硬化的危险因素。本研究旨在分析预测肝脏疾病进展的HBV标志物的预测作用。

研究方法:本研究纳入529例发生HBeAg血清学转换的患者。同时这些患者还符合FIB-4 index
研究结果:在随访期间,84例患者进展到肝硬化(FIB-4 index >3.6)。单变量Cox比例危险模型表明,血清HBsAg水平,HBV DNA载量,HBV核心相关抗原(HBcrAg),基础核心启动子(BCP)状态与疾病进展到肝硬化显著相关;而HBV 基因型,治愈前状态与疾病进展到肝硬化没有相关性。调整HBV基因型,血清HBsAg水平,HBV DNA载量,HBV核心相关抗原(HBcrAg),基础核心启动子(BCP)状态后,多变量Cox比例危险模型表明,HBsAg >/=3.0 log IU/ml (HR, 0.53; 95% CI, 0.30-0.94) 和 HBcrAg >/=3.7 log U/ml (HR, 3.28; 95% CI, 1.60-6.75)与疾病进展到肝硬化独立相关。HR样条曲线分析,随着HBcrAg levels逐渐增加,HR and 95% CI 在逐渐增加。相反,随着HBsAg 和HBV DNA水平增加,HBsAg 和HBV DNA的HRs and 95% Cis并没有随之增加。

研究结论:HBcrAg水平增加,增加了疾病进展到肝硬化程度的风险。HBcrAg是肝硬化发展的良好预测指标。

原始出处

Tada T, Kumada T, Toyoda H, et al. Hepatitis B virus core-related antigen levels predict progression to liver cirrhosis in hepatitis B carriers.J Gastroenterol Hepatol, 2017, Sep 15. doi: 10.1111/jgh.13989.

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    2018-09-18 klivis
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    2018-07-21 许安
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    2018-06-20 qblt
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    2017-11-29 gwc384
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