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Environ Sci Pollut Res Int:氧化石墨烯对生物膜形成的影响

2018-02-05 MedSci MedSci原创

在这项研究中,我们评估了氧化石墨烯(GO)对生物膜形成的影响。选用革兰氏阴性菌大肠杆菌MG1655和革兰氏阳性菌枯草芽孢杆菌168进行探究。生长曲线和活力测定表明,GO具有较高的抗菌活性,随着GO浓度的增加,抗菌能力增强。 已知GO的抗菌活性主要归因于膜应激和ROS决定的氧化应激。此外,值得注意的是,在低剂量的GO存在下生物膜形成增强,而在高浓度的GO环境中被抑制。而此结果可以用死亡细胞的作用来解

在这项研究中,我们评估了氧化石墨烯(GO)对生物膜形成的影响。

选用革兰氏阴性菌大肠杆菌MG1655和革兰氏阳性菌枯草芽孢杆菌168进行探究。生长曲线和活力测定表明,GO具有较高的抗菌活性,随着GO浓度的增加,抗菌能力增强。

已知GO的抗菌活性主要归因于膜应激和ROS决定的氧化应激。此外,值得注意的是,在低剂量的GO存在下生物膜形成增强,而在高浓度的GO环境中被抑制。而此结果可以用死亡细胞的作用来解释:当GO的浓度较低时,只有一部分细菌被灭活,死亡的细菌可能作为保护屏障以及作为剩余活细菌形成生物膜所需的营养。相反,在GO浓度较高的情况下,几乎所有的细菌都可以被完全灭活,因此生物膜无法形成。

总的来说,该研究结果为碳纳米材料对生物膜形成的影响提供了新的见解,这在生物污染和膜生物反应器领域具有深远的影响。

原始出处:

Song C, Yang CM, et al., Influences of graphene oxide on biofilm formation of gram-negative and gram-positive bacteria. Environ Sci Pollut Res Int. 2018 Jan;25(3):2853-2860. doi: 10.1007/s11356-017-0616-8. Epub 2017 Nov 15.

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    2018-02-07 july_979
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