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J Thromb Haemost:心肺健康与静脉血栓栓塞风险

2019-08-27 xing.T MedSci原创

由此可见,较高的eCRF与较低的VTE事件风险相关。该关联与体重无关,表明较高的eCRF可能会改变肥胖与VTE之间的关联。

心肺健康(CRF)是未来动脉心血管疾病和过早死亡的强有力预测因子。然而,关于CRF与发生静脉血栓栓塞(VTE)风险之间关联的数据十分有限。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在调查估计的CRF(eCRF)是否与VTE事件风险相关。 

研究人员纳入了Troms研究(2007-2008)第六次调查的参与者(n=10393),并记录了截至2016年12月31日的VTE事件。根据年龄、腰围、静息心率和自我报告体力活动的性别特异性算法估算eCRF。在Cox回归模型中计算了根据eCRF类别计算的VTE风险比(HR)和95%置信区间(CI),该模型根据年龄作为时间尺度进行性别调整。在按重量分类的分析中评估体重状态的影响。

在随访期间共发生了176起VTE事件。与eCRF<85%年龄预测的个体相比,eCRF为85-100%或>100%年龄预测的个体VTE风险分别降低46%(HR为0.54; 95%CI为0.39-0.77)和67%(HR为0.33; 95%CI为0.20-0.54)。与eCRF<85%年龄预测的超重/肥胖个体相比,eCRF≥85%的超重/肥胖患者风险降低50%(HR为0.50,95%CI为0.35-0.74),eCRF≥85%的正常体重患者风险降低55%( HR为0.45,95%CI为0.30-0.68)。

由此可见,较高的eCRF与较低的VTE事件风险相关。该关联与体重无关,表明较高的eCRF可能会改变肥胖与VTE之间的关联。 

原始出处:

Line H. Evensen.et al.Cardiorespiratory fitness and future risk of venous thromboembolism.Journal of Thrombosis and Haemostasis.2019.https://doi.org/10.1111/jth.14619

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    2019-09-05 fusion
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    2019-09-02 aids222
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    2019-09-15 xue8602
  6. [GetPortalCommentsPageByObjectIdResponse(id=1697963, encodeId=94d1169e96387, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Thu Sep 05 06:27:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928544, encodeId=ac541928544f9, content=<a href='/topic/show?id=6c2d513392c' target=_blank style='color:#2F92EE;'>#心肺健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51339, encryptionId=6c2d513392c, topicName=心肺健康)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6ac207, createdName=xlwang2691, createdTime=Wed Oct 16 02:27:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770089, encodeId=52231e7008969, content=<a href='/topic/show?id=14b99918664' target=_blank style='color:#2F92EE;'>#静脉血栓栓塞风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99186, encryptionId=14b99918664, topicName=静脉血栓栓塞风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b79338139346, createdName=ymljack, createdTime=Sun Oct 13 23:27:00 CST 2019, time=2019-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684538, encodeId=3c77168453809, content=<a href='/topic/show?id=dfae5133e1d' target=_blank style='color:#2F92EE;'>#心肺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51337, encryptionId=dfae5133e1d, topicName=心肺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8e128082444, createdName=aids222, createdTime=Mon Sep 02 10:27:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955450, encodeId=72d019554508f, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sun Sep 15 12:27:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008436, encodeId=33f020084369b, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Dec 15 21:27:00 CST 2019, time=2019-12-15, status=1, ipAttribution=)]
    2019-12-15 changfy

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