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ARCH PATHOL LAB MED:通过磁共振成像检测到的前列腺癌-靶向活组织检查具有较高的Gleason模式4组分百分比,并且在根治性前列腺切除术中不太可

2018-12-29 MedSci MedSci原创

在格里森评分(GS)7前列腺癌中,格里森模式4(GP4)的数量是一个重要的预后因素,并影响治疗决策。而磁共振成像(MRI)靶向活检已越来越多地用于临床实践。本项目旨在研究MRI靶向活检是否可以检测出更高GP 4量的GS 7前列腺癌,以及是否改善活检/根治性前列腺切除术GS一致性。 研究人员共对243名癌症患者进行了成对标准和MRI靶向活检,其中65名患者接受了根治性前列腺切除术。活检结果包括

在格里森评分GS7前列腺癌中,格里森模式4GP4)的数量是一个重要的预后因素,并影响治疗决策。而磁共振成像(MRI)靶向活检已越来越多地用于临床实践。本项目旨在研究MRI靶向活检是否可以检测出更高GP 4量的GS 7前列腺癌,以及是否改善活检/根治性前列腺切除术GS一致性。

研究人员共对243名癌症患者进行了成对标准和MRI靶向活检,其中65名患者接受了根治性前列腺切除术。活检结果包括GS和肿瘤体积,这与与根治性前列腺切除术相关。

通过MRI靶向活组织检查检测到的更多前列腺癌是GS7或更高。通过MRI靶向活检,GS 7癌症的平均GP 4百分比为31.0±29.3%,而标准活组织检查为25.1±29.5%。分别通过靶向活检和标准活检诊断218例(56.0%)和217例(44.2%)前列腺癌中共有122GP 410%或更高(P = .01)。在标准活检中,格里森升级与活检癌症体积相反,GP 430%或更低。在MRI靶向活组织检查中未发现这种相关性。

结果表明,核磁共振成像靶向活检可以检测出更具侵袭性的前列腺癌,并降低根治性前列腺切除术中格里森升级的风险。该研究支持MRI靶向活检在前列腺癌检查中的潜在作用,并在前列腺活检报告中包含GP 4的百分比。

原始出处:

Yani Zhao, Fang-Ming Deng,Prostate Cancers Detected by Magnetic Resonance Imaging–Targeted Biopsies Have a Higher Percentage of Gleason Pattern 4 Component and Are Less Likely to Be Upgraded in Radical Prostatectomies

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    2018-12-31 jeanqiuqiu
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    2019-07-21 huangdf

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