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ANN SURG:前列腺素E1对胃肠手术患者的影响

2018-03-27 MedSci MedSci原创

前列腺素E1(PGE1)可以增加内脏血供,被认为可以降低术后胃肠道并发症发生率。ANN SURG近期发表了一篇文章,研究PGE1对因胃肠道损伤、穿孔或梗阻接受手术的患者的影响。

前列腺素E1(PGE1)可以增加内脏血供,被认为可以降低术后胃肠道并发症发生率。ANN SURG近期发表了一篇文章,研究PGE1对因胃肠道损伤、穿孔或梗阻接受手术的患者的影响。

作者回顾性分析了889例接受胃肠手术患者的信息。在所有患者中评估包括胃肠功能恢复,术后并发症和住院时间长度等临床结果。在278对匹配患者中,比较营养,免疫和炎症等变量。配对后两组间基线相似。PGE1与促进术后胃肠功能恢复有关,包括第一次肠蠕动以及术后第一次进食时间。接受PGE1治疗的患者中总术后并发症发生率(包括感染性并发症和主要并发症)降低。此外,PGE1治疗组免疫学和炎症指标C反应蛋白在术后3天降低。

文章最后认为,PGE1与临床获益有关,如促进术后胃肠功能恢复及降低急诊胃肠手术总术后并发症发生率,其原因可能与降低炎症反应有关。

原始出处:
Hao Fabao,Guo Hongjie,et al.Effects of Prostaglandin E1 on Patients Undergoing Major Gastrointestinal Surgery.ANN SURG.April 2018 doi:10.1097/SLA.0000000000002152

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1744856, encodeId=db0a1e4485666, content=<a href='/topic/show?id=37c3325555a' target=_blank style='color:#2F92EE;'>#前列腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32555, encryptionId=37c3325555a, topicName=前列腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e7035453721, createdName=makuansheng, createdTime=Wed Jul 04 22:21:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300151, encodeId=db2a3001513a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Tue Mar 27 09:10:11 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300143, encodeId=da1630014363, content=谢谢分享.学习了谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Mar 27 08:44:44 CST 2018, time=2018-03-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1744856, encodeId=db0a1e4485666, content=<a href='/topic/show?id=37c3325555a' target=_blank style='color:#2F92EE;'>#前列腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32555, encryptionId=37c3325555a, topicName=前列腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e7035453721, createdName=makuansheng, createdTime=Wed Jul 04 22:21:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300151, encodeId=db2a3001513a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Tue Mar 27 09:10:11 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300143, encodeId=da1630014363, content=谢谢分享.学习了谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Mar 27 08:44:44 CST 2018, time=2018-03-27, status=1, ipAttribution=)]
    2018-03-27 海之蓝

    学习

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    2018-03-27 明月清辉

    谢谢分享.学习了谢谢分享.学习了

    0

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