CCLM：在多中心研究的基础上建立健康中国成年男性性激素和SHBG的参考区间

2018-07-05 MedSci MedSci原创

性激素测定对于诸如睾丸功能障碍、男性不育和女性化综合症等健康问题至关重要。然而，目前在中国男性中没有关于参考区间(RIs)的报告。我们在全国范围内开展了一项多中心研究，建立了七种性激素的参考区间，包括促黄体生成素[LH]、促卵泡激素[FSH]、催乳素[PRL]、总睾酮[TT]、游离睾酮[FT]、生物可利用睾酮[BAT]和雌激素[E2]以及性激素结合球蛋白[SHBG]。研究人员于2013年，

性激素测定对于诸如睾丸功能障碍、男性不育和女性化综合症等健康问题至关重要。然而，目前在中国男性中没有关于参考区间(RIs)的报告。我们在全国范围内开展了一项多中心研究，建立了七种性激素的参考区间，包括促黄体生成素[LH]、促卵泡激素[FSH]、催乳素[PRL]、总睾酮[TT]、游离睾酮[FT]、生物可利用睾酮[BAT]和雌激素[E2]以及性激素结合球蛋白[SHBG]。

研究人员于2013年，从中国五个代表性城市(北京、杭州、广州、大连、乌鲁木齐)招募了1043名健康成年男性;使用自动免疫分析仪测量激素。采用多元回归分析(MRA)确定可能影响激素血清水平的变异来源。用参数法计算RIs。

结果显示，来自大连和杭州的受试者E2值显著高于其他城市;年龄是FSH、LH、PRL、SHBG、FT和BAT的主要变异来源。FSH、LH和SHBG随着年龄的增长而显著增加，PRL、FT和BAT则随着年龄的增长而减少。TT没有明显的年龄变化。未按年龄划分的中位数(RIs)如下:FSH, 5.6 (1.9-16.3) IU/L;LH:4.2(1.6 - -10.0)IU / L;PRL,189(88 - 450)个人/ L;E2,85(4.7 -195)pmol / L;,SHBG 29.4 nmol / L(11.5 - -66.3);TT,15.6 nmol / L(7.4 - -24.5); FT,0.31 nmol / L(0.16 - -0.52);和BAT, 8.0 (3.7-13.2) nmol/L。同时，RIs也是根据城市间和年龄之间的差异得出的。

本研究在考虑到年龄的情况下，在健康中国男性中建立了性激素和SHBG的参考区间。

原始出处：

Yu, Songlin., Establishing reference intervals for sex hormones and SHBG in apparently healthy Chinese adult men based on a multicenter study

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2019-06-05 redcrab

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2018-12-12 luoxiaog

#多中心#

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2018-07-06 wangyang7958

#性激素#

68 0
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2018-07-06 12498dabm81暂无昵称

#参考区间#

77 0
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2018-07-06 zhty5343

#SHBG#

86 0
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2018-07-06 cici-moon

不错的研究.范围要扩大才好

146 0
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2018-07-05 wzb521zf

一起学习学习

107 0
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2018-07-05 1ddf0692m34(暂无匿称)

学习了.谢谢分享

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