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Diabetes Care:糖化血红蛋白可预测儿童2型糖尿病

2016-11-06 xing.T MedSci原创

糖化血红蛋白是一个有用的儿童糖尿病风险预测指标,与其他2型糖尿病危险因素一样,这些危险因素跟空腹血糖和餐后2小时血糖有着相同儿童糖尿病的预测价值,可用于识别儿童中糖尿病前期患者。

长期研究数据证实用糖化血红蛋白来评估儿童2型糖尿病的发生风险的作用是有限的。近日,糖尿病领域权威杂志Diabetes Care发表了一篇研究文章,在以美洲印第安人为基础的纵向研究中,研究者通过测量糖化血红蛋白、空腹血糖和餐后2小时血糖的浓度来确定他们预测糖尿病发生的效能。

研究者比较了2095例年龄在10-19岁之间的非糖尿病儿童到39岁时和2005例年龄在20-39岁之间的成年人到59岁时糖尿病(空腹血糖≥126mg/dL[7 mmol/L],餐后2小时血糖≥200mg/dL[11.1 mmol/L],糖化血红蛋白≥6.5%[8 mmol/mol ],或临床诊断)的发生率。同时,研究者还比较了受试者的糖化血红蛋白、空腹血糖和餐后2小时血糖的ROC曲线的曲线下面积,并预测10年内糖尿病的发生率。

在最初没有糖尿病的儿童和青少年的长期随访期间,研究者发现,糖化血红蛋白≥5.7%的儿童和糖化血红蛋白≤5.3%的儿童相比,糖化血红蛋白≥5.7%的儿童糖尿病发病率超过4倍(男孩)或超过7倍(女孩);在成人中糖化血红蛋白≥5.7%的参与者在后续随访过程中糖尿病的发病率比糖化血红蛋白≤5.3%的参与者更高,而且增加的幅度要比儿童还要高。通过分析ROC显示,用糖化血红蛋白、空腹血糖以及餐后2小时血糖来预测随访后期发生糖尿病的儿童和青少年的敏感性和特异性并无明显差异。

由此可见,糖化血红蛋白是一个有用的儿童糖尿病风险预测指标,与其他2型糖尿病危险因素一样,这些危险因素跟空腹血糖和餐后2小时血糖有着相同儿童糖尿病的预测价值,可用于识别儿童中糖尿病前期患者。

原始出处:

Pavithra Vijayakumar, et al. HbA1c and the Prediction of Type 2 Diabetes in
Children and Adults
. Diabetes Care.

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    2016-11-07 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

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    2016-11-07 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

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