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Diabetes Care:低羟基维生素D状态或示葡萄糖稳态恶化

2012-06-28 范伟伟译 医学论坛网

  来自丹麦哥本哈根大学的一项研究证实,在校正混杂因素后,血清低25-羟维生素D [25(OH)D]水平与糖尿病的发病风险不存在显著相关关系。然而,低25(OH)D水平与葡萄糖稳态连续标志物的不良纵向变化相关,表明低维生素D状态可能与葡萄糖稳态恶化相关。研究在2012年6月11日在线发表于《糖尿病护理》(Diabetes Care)杂志。   该研究旨在评价维生素D水平是否构

  来自丹麦哥本哈根大学的一项研究证实,在校正混杂因素后,血清低25-羟维生素D [25(OH)D]水平与糖尿病的发病风险不存在显著相关关系。然而,低25(OH)D水平与葡萄糖稳态连续标志物的不良纵向变化相关,表明低维生素D状态可能与葡萄糖稳态恶化相关。研究在2012年6月11日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  该研究旨在评价维生素D水平是否构成2型糖尿病和葡萄糖稳态恶化进展的决定性因素。研究作为Inter99研究的一部分,采用从丹麦哥本哈根总人口中随机抽样的方法入选受试者。基线时(1999-2001年)共纳入年龄在30-65岁的男性和女性受试者6405例,4296例参加了后续的5年随访观察(2004-2006年)。在基线时通过血清25-羟维生素D检测确定维生素D 水平。糖尿病的诊断通过口服糖耐量试验(OGTT)和糖化血红蛋白(HbA1c)测试。次要终点包括葡萄糖稳态的连续标志物。

  原始分析结果表明,糖尿病的发病风险与10 nmol / L的25(OH)D增量相关,比值比(OR)为0.91(95%CI为0.84-0.97)。在校正混杂因素后,该相关关系未达到统计学上的显著性,OR为0.94(0.86-1.03)。校正混杂因素后,低25(OH)D状态与葡萄糖稳态连续标志物的不良纵向变化相关。与较高25(OH)D水平受试者相比,低25(OH)D水平者的空腹和2小时的血糖和胰岛素水平、胰岛素抵抗程度在随访过程中明显增加。

      

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    2013-03-20 changfy
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