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EBioMedicine:科学家发现特殊细菌或与胆管癌直接相关

2016-06-28 佚名 生物谷

近日,来自新加坡A*STAR研究所的研究人员通过研究发现,胆管中的一种细菌或是引发胆管癌(Bile Duct Cancer)的一种潜在风险因素,胆管上皮癌(CCA)是一种罕见但非常恶性的胆管癌,这种癌症在早期并不会表现出任何症状。胆管上皮癌的发病和多种风险因子有关,而这些因子的地理位置明显不同,胆管囊肿和原发性硬化性胆管炎被认为和西方人群患CCA直接相关,肝脏中感染寄生虫也会导致东南亚人群较高的C


近日,来自新加坡A*STAR研究所的研究人员通过研究发现,胆管中的一种细菌或是引发胆管癌(Bile Duct Cancer)的一种潜在风险因素,胆管上皮癌(CCA)是一种罕见但非常恶性的胆管癌,这种癌症在早期并不会表现出任何症状。

胆管上皮癌的发病和多种风险因子有关,而这些因子的地理位置明显不同,胆管囊肿和原发性硬化性胆管炎被认为和西方人群患CCA直接相关,肝脏中感染寄生虫也会导致东南亚人群较高的CCA发生率,然而细菌在CCA发生过程中的角色此前研究者并不清楚。本文研究中研究人员就基于对16S RNA基因进行研究阐明了肝脏意外感染和非感染的CCA患者机体中的微生物群落。16S RNA是一种研究不同细菌谱系的保守标记基因。

文章中,研究者发现,胆管组织中包含了多种细菌群落,而且此前认为和胆管感染相关的寡养单胞菌(Stenotrophomonas)群落也被发现可以优先寄居到非意外感染的CCA患者机体的肿瘤组织中,这就揭示了细菌在CCA发病过程中的关键角色。相比非意外感染的CCA患者而言,意外感染CCA患者的机体组织包含有多种肠细菌,而这些肠细菌的代谢产物比如胆汁酸等都和致癌过程或癌症发生直接相关。

总的来讲,本文研究结果揭示了单管组织微生物组在胆管上皮癌发生中的关键作用,相关研究刊登于EbioMedicine杂志上;研究者Nagarajan说道,截止到目前为止,我们对机体细菌群落和疾病发生的关系理解得并不深入,本文研究结果为阐明细菌在胆管癌发病中的角色提供了确凿的证据,我们希望该研究可以帮助我们加速寻找治疗胆管上皮癌的新型疗法。

最后研究者Joanne Ngeow说道,理解机体细胞同环境之间的相互作用,以及微生物自身扮演的关键角色,对于后期我们进行机体健康和疾病研究非常重要,后期我们还会继续投入更大的精力来研究人类机体微生物组同机体疾病发病的关联。

原始出处

Kern Rei Chng, Sock Hoai Chan, Amanda Hui Qi Ng.et.al.Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.EBioMedicine.2016

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    2017-01-30 linagood
  2. [GetPortalCommentsPageByObjectIdResponse(id=1997082, encodeId=9619199e08211, content=<a href='/topic/show?id=9221645e6f' target=_blank style='color:#2F92EE;'>#EBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6457, encryptionId=9221645e6f, topicName=EBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Jan 30 06:13:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917295, encodeId=9ddc191e2954b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue May 02 08:13:00 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773556, encodeId=ccb21e73556fe, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Jul 24 14:13:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802330, encodeId=89241802330c8, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Wed Jun 14 05:13:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858681, encodeId=75f11858681e0, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Aug 26 01:13:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91947, encodeId=67d89194e78, content=近年来微生态研究非常热,尤其是肠道,不过既然都是大环境,认识是一方面,过多地干预会不会有更大的隐患, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue Jul 05 08:14:00 CST 2016, time=2016-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577477, encodeId=f19c15e74770b, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Thu Jun 30 11:13:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606965, encodeId=6244160696578, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Jun 30 11:13:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628267, encodeId=2592162826ead, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Jun 30 11:13:00 CST 2016, time=2016-06-30, status=1, ipAttribution=)]
    2017-05-02 sunylz
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    2016-07-24 kalseyzl
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    2016-08-26 jeanqiuqiu
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    2016-07-05 吴教授

    近年来微生态研究非常热,尤其是肠道,不过既然都是大环境,认识是一方面,过多地干预会不会有更大的隐患

    0

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