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JAAD:吲哚美辛治疗阴囊灼烧综合征效果或更佳

2021-08-19 网络 网络

在JAAD 病例报告6 月版中,Hwang 等人报道了消炎痛成功用于 BSS。吲哚美辛的血管收缩特性或可取得更好的疗效。

阴囊灼烧综合征 (BSS)又称红色阴囊综合征,是一种病因不明且难以治疗的疾病其特征是阴囊持续性红斑;阴囊疼痛和灼烧感;对局部治疗无反应BSS 的机制被人认为可能与使用皮质类固醇血管扩张反弹、局部神经源性炎症、局部红斑性肢痛症和酒渣鼻样血管扩张有关

有一些病例报道了使用局部钙调神经磷酸酶抑制剂、强力霉素、加巴喷丁、普瑞巴林、局部和口服β受体阻滞剂和肉毒杆菌毒素,并取得一定的成效但是现在仍然缺乏安慰剂对照试验或共识指南来指导临床医生用药。

JAAD 病例报告6 月版中,Hwang 等人报道了消炎痛成功用于 BSS。尽管对他克莫司、多西环素和布洛芬等进行了试验,但患者的阴囊红斑和烧灼感持续超过 18 个月。他报告在开始服用 50 毫克吲哚美辛 10 天,每天 3 次后,他的症状有 70% 的改善,4 周后有 100% 的改善共持续了 6 周的治疗,停药后出现轻微的斑,在短时间内重新开始服用较低剂量的药物后立即停止。开始治疗五个月后,他没有任何不适症状,也不再需要消炎痛。

作者推测,快速缓解是由于吲哚美辛的血管收缩特性,特别是它对肠系膜血流的影响。尽管布洛芬也是一种非甾体抗炎药,但尚未显示出能改变肠系膜血流。睾丸动脉起源于主动脉的 L2-L3 椎体区域,肠系膜上动脉和肠系膜下动脉分别起源于 L1 区域上方和 L3 区域下方。鉴于这种接近,Hwang 等人假设吲哚美辛对睾丸动脉具有类似的作用,可有效治疗 BSS。

虽然需要进一步的研究来评估疗效和安全性,但病理生理机制很有趣,并为治疗这种困难的疾病提供了另一种潜在的选择。

 

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    2021-10-16 vera_1210
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    2021-08-19 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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