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Clin Cancer Res:怎么预测卵巢癌治疗效果?

2017-07-15 佚名 康健新视野

卵巢癌是女性癌症的三大杀手之一。晚期的卵巢癌在初步治疗后有着非常高的复发率,高达 60%-85% 的患者都会经历复发。治疗计划是患者治疗中很重要的因素,但是目前很少有可靠的选择来帮助医生精确做出治疗计划,以及筛选哪些患者可以作为特定治疗方案的候选人。


研究的领导者 Ting-Yim Lee 教授 图片来源: Western University

卵巢癌是女性癌症的三大杀手之一。晚期的卵巢癌在初步治疗后有着非常高的复发率,高达 60%-85% 的患者都会经历复发。治疗计划是患者治疗中很重要的因素,但是目前很少有可靠的选择来帮助医生精确做出治疗计划,以及筛选哪些患者可以作为特定治疗方案的候选人。

如果能够通过较为科学的证据来评估患者可能产生的治疗结果,对于卵巢癌的治疗和存活率将是非常有帮助的。

来自加拿大西安大略大学和罗森健康研究中心的研究人员最近在杂志《Clinical Cancer Research》上表示,通过 CT 灌注技术可以预测卵巢癌患者对于治疗的缓解情况。团队开发了相关的方法,通过 CT 灌注对肿瘤在治疗前后的血流改变情况进行评价,使用 X - 射线染料及常规 CT 扫描仪即可完成。虽然,这项技术在世界范围内都用于中风治疗后脑部血流的测量,这是首次 CT 灌注应用于卵巢癌患者。

横跨美国 19 个中心的多中心临床试验,共入组了 120 例患者,试验表明,治疗后肿瘤附近的血流增加的患者会在六个月内经历复发,血流减低的患者则可以高枕无忧。

研究的领导者 Ting-Yim Lee 教授表示,这项技术的主要益处是能够及时的(治疗后四周)评估血流情况,而不需要在复发之前等待数月。因此,治疗的有效性评估得以大大的提前,如果有需要,允许医生精确及时的制定后续的治疗计划。

研究还引入了一种独特的生物标志物,用于未来的新型治疗方案的研究。

原始出处:

Chaan S. Ng, Zheng Zhang, Susanna I. Lee, et al. CT Perfusion as an Early Biomarker of Treatment Efficacy in Advanced Ovarian Cancer: An ACRIN and GOG Study. Clinical Cancer Research, 2017. DOI: 10.1158/1078-0432.CCR-16-1859 Published July 2017.

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    2017-07-18 luominglian113

    学习了,谢谢分享

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1893971, encodeId=11fd18939e1e8, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Tue Feb 06 15:38:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=223340, encodeId=60de223340fc, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Tue Jul 18 00:38:52 CST 2017, time=2017-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222660, encodeId=f5bd22266044, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 15 19:39:25 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222574, encodeId=6dc72225e491, content=很好的文章谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 15 12:03:50 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222520, encodeId=066a222520c3, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jul 15 09:45:26 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222494, encodeId=e1a7222494f1, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 15 08:54:48 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222484, encodeId=869a22248442, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Jul 15 08:42:39 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 luominglian113

    学习了,谢谢分享

    0

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    2017-07-15 清风拂面

    很好的文章谢谢分享

    0

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    2017-07-15 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

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    2017-07-15 楠博One

    学习谢谢分享

    0

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    2017-07-15 Jackie Li

    学习

    0

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