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CELL REP:为什么有些人不容易感冒?

2018-09-13 海北 MedSci原创

最近,来自耶鲁大学医学院的研究人员通过研究离体培养的原代人鼻腔和支气管气道上皮细胞的抗病毒防御机制,试图更好地了解宿主对鼻病毒的防御

鼻病毒是引起急性呼吸道感染和哮喘发作的主要原因,但也经常从鼻粘膜中被清除,而不引起症状。
最近,来自耶鲁大学医学院的研究人员通过研究离体培养的原代人鼻腔和支气管气道上皮细胞的抗病毒防御机制,试图更好地了解宿主对鼻病毒的防御。令人惊讶的是,在鼻病毒感染或RIG-1刺激后,鼻源性上皮细胞表现出比支气管衍生细胞更强的抗病毒反应。
相反,与鼻细胞相比,RIG-I刺激引发支气管细胞中NRF2依赖性氧化应激反应的更强烈的激活。 NRF2激活抑制上皮抗病毒反应,而NRF2敲低增强了抗病毒反应,并且在鼻病毒感染期间具有保护作用。
这些发现证明了上皮防御对不同类型的气道损伤(即病毒与氧化)之间的权衡,并揭示了源自不同气道微环境的细胞中防御反应的差异校准。

原始出处:
Valia T.Mihaylova et al. Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus. CELL REPORT 2018, DOI: https://doi.org/10.1016/j.celrep.2018.08.033

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    2019-03-16 维他命
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    2018-09-13 flysky120

    不应该感冒还是免疫力好吧

    0

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    2018-09-13 183****7028

    学习

    0

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    2018-09-13 明月清辉

    谢谢分享,学习了

    0

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    2018-09-13 太阳系小猪

    不容易感冒的人,还是因为免疫力强呗~

    0

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