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ASCO2017 :VEGFR2 单抗用于复发性胶质母细胞瘤

2017-06-06 zhangfan MedSci原创

对于复发性胶质母细胞瘤患者,Tanibirumab具有较高的安全性且最长的病情稳定期长达10个月

目前复发性胶质母细胞瘤(GBM)的治疗仍面临很大的挑战,研究发现GBM中VEGF信号通路上调,针对这一现象,研究人员开展了Tanibirumab,一种VEGFR2单克隆抗体的II期研究。主要终点是安全性和疗效。

招募的患者为19岁以上的,首次或2次GBM复发,KPS≥80,无贝伐单抗使用史的患者,随机分配接受3种治疗方案,第一组(8mg/kg d1,8,15/q28天)、第二组(12mg/kg d1,8,15/q28天)、第三组 (12mg/kg 每周)。

共招募了12名患者,其中第一二组各3人,第三组6人,平均年龄50岁,8人为男性。在第一轮治疗中,有8名患者基线时使用皮质激素。研究中未发生剂量限制性毒性(DLT)但83%的患者发生皮肤血管瘤(CH)。无药物相关的3级以上不良事件。12名患者无明显的客观缓解,但3名患者病情稳定,2名患者在4轮治疗后病情稳定并持续治疗至45周。

研究认为,对于复发性胶质母细胞瘤患者,Tanibirumab具有较高的安全性且最长的病情稳定期长达10个月。

原始出处:


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encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407285, encodeId=6472140e28541, content=<a href='/topic/show?id=d5b01834e3a' target=_blank style='color:#2F92EE;'>#VEGFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18347, encryptionId=d5b01834e3a, topicName=VEGFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d8d2627959, createdName=jml2010, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475824, encodeId=773714e582426, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534305, encodeId=d0491534305ad, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537085, encodeId=7d3b153e085a3, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-11-16 quxin068
  5. 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channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534305, encodeId=d0491534305ad, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537085, encodeId=7d3b153e085a3, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 luominglian113

    学习了,谢谢分享

    0

  6. 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  7. 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href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 jml2010
  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1772229, encodeId=12e71e7222997, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Fri Feb 02 16:38:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909634, encodeId=7b20190963459, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407285, encodeId=6472140e28541, content=<a href='/topic/show?id=d5b01834e3a' target=_blank style='color:#2F92EE;'>#VEGFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18347, encryptionId=d5b01834e3a, topicName=VEGFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d8d2627959, createdName=jml2010, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475824, encodeId=773714e582426, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534305, encodeId=d0491534305ad, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537085, encodeId=7d3b153e085a3, content=<a href='/topic/show?id=48274255263' target=_blank style='color:#2F92EE;'>#复发性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42552, encryptionId=48274255263, topicName=复发性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61112794032, createdName=charl1234571, createdTime=Thu Jun 08 00:38:00 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 liuyiping
  10. 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