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Cell Rep:科学家找到治疗滤泡性淋巴瘤的关键

2019-02-23 顾然 生物探索

“T细胞在人体对抗滤泡性淋巴瘤(follicular lymphoma)的过程中起着至关重要的作用。”这是梅奥诊所(Mayo Clinic)血液学家Zhi Zhang Yang和Stephen Ansell领导的一项研究得出的结论。研究结果发表在《Cell Reports》杂志上。T细胞是免疫系统的关键部分,通过对抗感染和癌症来保护身体。“滤泡淋巴瘤是一种主要累及体内淋巴结的血癌,”Yang说,虽

“T细胞在人体对抗滤泡性淋巴瘤(follicular lymphoma)的过程中起着至关重要的作用。”这是梅奥诊所(Mayo Clinic)血液学家Zhi Zhang Yang和Stephen Ansell领导的一项研究得出的结论。研究结果发表在《Cell Reports》杂志上。

T细胞是免疫系统的关键部分,通过对抗感染和癌症来保护身体。

“滤泡淋巴瘤是一种主要累及体内淋巴结的血癌,”Yang说,虽然这种疾病很常见,而且预后比其他癌症要好,但它是无法治愈的。即便许多病人对治疗有反应,但癌症在治疗后复发是很常见的。

Yang博士和他的同事们很好奇为什么有些滤泡淋巴瘤患者的病情比其他患者要好。他们的研究发现,对这种疾病免疫应答较差的患者T细胞上的共刺激受体较少。

“细胞表面存在共刺激受体,使免疫系统能够更好地识别和攻击癌细胞,”Yang博士说。“我们还发现,在滤泡淋巴瘤患者中,T细胞缺乏共刺激受体的患者比T细胞表现出共刺激受体的患者生存时间明显短。”

Yang医生说,虽然这项研究还处于临床前和初步阶段,但最终可能会有临床意义。“如果我们能实施一项策略,在这种T细胞亚群的患者中恢复共刺激受体的表达,我们可能会开发出一种新的治疗滤泡淋巴瘤的方法。”

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