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J Thromb Haemost:新型冠状病毒性肺炎患者的凝血参数异常与预后不良有关

2020-02-19 xing.T MedSci原创

该研究的结果表明,异常凝血结果,尤其是D-二聚体和FDP明显升高,在NCP死亡病例中很常见。

最近在中国武汉爆发的新型冠状病毒感染中,严重的新型冠状病毒性肺炎(NCP)病例凝血参数明显异常是令人关注的问题。

近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在描述NCP患者的凝血功能。研究人员回顾性地分析了同济医院183例确诊NCP患者的常规凝血结果及结局。

NCP患者的总体死亡率为11.5%,与幸存者相比,非幸存者入院时有更高的D-二聚体和纤维蛋白降解产物(FDP)水平,更长的凝血酶原时间和活化的部分凝血活酶时间(P<0.05)。71.4%的非幸存者和0.6%的幸存者在住院期间符合弥散性血管内凝血的标准。

该研究的结果表明,异常凝血结果,尤其是D-二聚体和FDP明显升高,在NCP死亡病例中很常见。

原始出处:

Ning Tang.et al.Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.Journal of Thrombosis and Haemostasis.2020.https://onlinelibrary.wiley.com/doi/10.1111/jth.14768

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    2020-10-15 howi
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    2020-03-28 changfy
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