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Diabetes:蔗糖非发酵相关蛋白激酶可调控脂肪炎和能量平衡,为治疗肥胖及其相关疾病提供新的靶点。

2018-01-04 MedSci MedSci原创

蔗糖非发酵相关蛋白激酶(SNRK)是AMPK相关激酶家族的一员,其在脂肪能量平衡和炎症中的生理作用尚不清楚。既往有报道认为,SNRK在白色脂肪(WAT)和棕色脂肪(BAT)组织中普通且大量表达,但肥胖时,脂肪SNRK表达水平下降。Li Jie等人在其最新研究中发现SNRK对于存活至关重要,因为SNRK总体性缺失的幼崽在出生后24小时内死亡。SNRK杂合缺失小鼠常出现白色脂肪感染,棕色脂肪减少。特异

蔗糖非发酵相关蛋白激酶(SNRK)是AMPK相关激酶家族的一员,其在脂肪能量平衡和炎症中的生理作用尚不清楚。既往有报道认为,SNRK在白色脂肪(WAT)和棕色脂肪(BAT)组织中普通且大量表达,但肥胖时,脂肪SNRK表达水平下降。

Li Jie等人在其最新研究中发现SNRK对于存活至关重要,因为SNRK总体性缺失的幼崽在出生后24小时内死亡。SNRK杂合缺失小鼠常出现白色脂肪感染,棕色脂肪减少。特异性敲除脂肪组织的SNRK可引起白色脂肪感染、肝脏和肌肉中异位脂肪沉积、棕色脂肪的适应性发热作用障碍。

上述代谢异常又导致能量消耗减少、体重增加和胰岛素抵抗。研究人员还进一步证明了SNRK基因的常见突变与人类肥胖风险有显着的相关性。通过磷酸化蛋白质组学的方法,研究人员证实真核延伸因子1δ(EEF1δ)和组蛋白去乙酰化酶1/2(HDAC1/2)是SNRK潜在的底物。

总而言之,Li Jie等人证实SNRK是白色脂肪炎的抑制剂,且对于维持棕色脂肪适应性发热作用至关重要,这一发现,为治疗肥胖及其相关疾病提供一个新的潜在治疗靶点。

原始出处:

Li Jie,et al.Sucrose Non-Fermenting Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.Diabetes  2018 Jan;  db170745.  https://doi.org/10.2337/db17-0745

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    2018-01-06 redcrab
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    2018-01-06 yangfl11

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