Heart：脂蛋白(a)与主动脉瓣钙化密切相关

2021-05-08 MedSci原创 MedSci原创

xing.T

上海市第一妇婴保健院医生/ 主治医师

Lp（a）水平与AVC之间密切相关。这些结果为评估降低Lp（a）对AVC早期患者进行干预以预防终末期主动脉瓣狭窄提供了理论依据。

近日，心脏病领域权威杂志Heart上发表了一篇研究文章，该研究通过根据年龄和脂蛋白（a）（Lp（a））水平进行分层的两个大型队列，来调查主动脉瓣钙（AVC）的患病率和数量，并评估Lp（a）与AVC之间的关联。

研究人员纳入了基于人群的鹿特丹研究中2412名参与者（52％为女性，平均年龄为69.6±6.3岁）以及来自阿姆斯特丹大学医学中心（UMC）门诊的859名健康个体（57％为女性，平均年龄为45.9±11.6岁）。

所有个体均接受血液采样以测定Lp（a）浓度，并接受了非增强型心脏CT评估AVC。研究人员进行了Logistic和线性回归分析以调查Lp（a）水平与有无AVC及其数量之间的关联。

脂蛋白(a)与主动脉瓣钙化的关系

在鹿特丹研究中AVC的患病率为33.1％，在阿姆斯特丹UMC队列中为5.4％。在两个队列中，较高的Lp（a）浓度与AVC独立相关（在Lp（a）水平每增加50mg/dL，OR分别为：鹿特丹研究队列中为1.54（95％CI为1.36至1.75）；阿姆斯特丹UMC队列中为2.02（95％CI为1.19至3.44）。在鹿特丹研究队列中，较高的Lp（a）浓度还与主动脉瓣Agatston得分增加相关（每增加50mg/dL，β为0.19，95％CI为0.06至0.32）。

由此可见，Lp（a）水平与AVC之间密切相关。这些结果为评估降低Lp（a）对AVC早期患者进行干预以预防终末期主动脉瓣狭窄提供了理论依据。

原始出处：

Yannick Kaiser.et al.Lipoprotein(a) is robustly associated with aortic valve calcium.heart.2021.https://heart.bmj.com/content/early/2021/05/07/heartjnl-2021-319044

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2021-05-10 hittouch

#主动脉瓣#

46 0
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2021-05-10 zhaojie88

#ART#

60 0
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2021-05-10 circumcision

#主动脉#

51 0
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2021-05-10 juliusluan79

#脂蛋白#

50 0
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2021-05-10 slcumt

#HEART#

49 0
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2021-05-10 respect

#主动脉瓣钙化#

79 0

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