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NEJM:支原体肺炎相关的粘膜炎-病例报道

2018-09-27 xing.T MedSci原创

支原体通常与疹病有关。在这种情况下,临床表现与肺炎支原体诱导的多形性红斑一致,也称为支原体诱导的皮疹和粘膜炎。鉴于粘膜受累的严重程度,该患者放置鼻胃管用于给予营养和药物。

患者为一名26岁的健康男子,因发热、干咳和非瘙痒性皮疹3天而到急诊就诊。

体格检查发现左侧胸部噼啪声,手部和脚上可见黄斑、皮疹,累及手掌和脚掌。胸部X线片显示左下肺野浸润。在接下来的3天内,发展为严重的粘膜炎,累及嘴唇、颊粘膜(如图A所示)、结膜和尿道口。对血液和痰液细菌培养物和来自口腔病变的标本进行聚合酶链反应(PCR)检查单纯疱疹病毒均为阴性。通过鼻咽抽吸物的PCR和血清IgM抗体检测到肺炎支原体阳性。



支原体通常与疹病有关。在这种情况下,临床表现与肺炎支原体诱导的多形性红斑一致,也称为支原体诱导的皮疹和粘膜炎。鉴于粘膜受累的严重程度,该患者放置鼻管用于给予营养和药物。

在用强力霉素治疗约2周后,患者呼吸道病变和粘膜炎完全消除(如图B所示)。

原始出处:

Timothy Li,et al. Mycoplasma pneumoniae–Associated Mucositis.N Engl J Med 2018; https://www.nejm.org/doi/full/10.1056/NEJMicm1800879

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    2018-12-23 guoyibin
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    2018-10-05 治皮医性的马大夫

    皮肤科医生来学习一下

    0

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    2018-09-28 galeno

    学习了

    0

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    2018-09-27 183****7028

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1691004, encodeId=bb5516910044c, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Sun Dec 23 17:59:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348078, encodeId=aed93480e8c6, content=皮肤科医生来学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/27/9730963e457610cfea211dbb4094b7b9.jpg, createdBy=c03e1820196, createdName=治皮医性的马大夫, createdTime=Fri Oct 05 22:50:05 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614715, encodeId=94411614e1589, content=<a href='/topic/show?id=1f0a5e0662f' target=_blank style='color:#2F92EE;'>#支原体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57066, encryptionId=1f0a5e0662f, topicName=支原体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fb019527746, createdName=ms5906905816781247, createdTime=Fri Sep 28 23:59:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347101, encodeId=509734e101be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=06e71731984, createdName=galeno, createdTime=Fri Sep 28 09:35:54 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346898, encodeId=2a0c34689850, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Thu Sep 27 10:56:39 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346895, encodeId=06c13468950c, content=诊断与治疗都是挺好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 27 10:08:34 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346890, encodeId=82a9346890df, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Thu Sep 27 09:10:26 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346882, encodeId=eed3346882bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Sep 27 09:07:29 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 flysky120

    诊断与治疗都是挺好的

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1691004, encodeId=bb5516910044c, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Sun Dec 23 17:59:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348078, encodeId=aed93480e8c6, content=皮肤科医生来学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/27/9730963e457610cfea211dbb4094b7b9.jpg, createdBy=c03e1820196, createdName=治皮医性的马大夫, createdTime=Fri Oct 05 22:50:05 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614715, encodeId=94411614e1589, content=<a href='/topic/show?id=1f0a5e0662f' target=_blank style='color:#2F92EE;'>#支原体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57066, encryptionId=1f0a5e0662f, topicName=支原体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fb019527746, createdName=ms5906905816781247, createdTime=Fri Sep 28 23:59:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347101, encodeId=509734e101be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=06e71731984, createdName=galeno, createdTime=Fri Sep 28 09:35:54 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346898, encodeId=2a0c34689850, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Thu Sep 27 10:56:39 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346895, encodeId=06c13468950c, content=诊断与治疗都是挺好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 27 10:08:34 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346890, encodeId=82a9346890df, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Thu Sep 27 09:10:26 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346882, encodeId=eed3346882bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Sep 27 09:07:29 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 lietome15

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2018-09-27 龙胆草

    学习谢谢分享

    0

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由肺炎支原体引起的肺炎,曾称原发性非典型性肺炎,常见呼吸系统传染病,本病呈世界分布,以温带为主。全年均有发生,以秋季为主。呈周期性流行,间隔约4~5年,发病数可较常年高3~5倍。本病多在家庭、军队、学校或集体住宅区内流行,或呈地区性流行。本病起病缓慢,有发热、阵发性刺激性咳嗽,少量黏液性或黏液脓性痰(偶有血痰)。肺部体征多不明显,但易引起肺外多系统受累,也可威胁生命或死亡。好发于儿童或青少年,

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