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cell:研究发现流感病毒致死机制

2011-09-22 MedSci原创 MedSci原创

       美国斯克里普斯研究所的科学家通过最新研究发现了流感病毒使感染者病重甚至死亡的机制。相关研究发表在9月16日出版的《细胞》杂志上。        研究人员将这种流感致死的免疫过程称为“细胞因子风暴”,可以预测病毒感染过程的发病率和死亡率,其被认为是1918-

       美国斯克里普斯研究所的科学家通过最新研究发现了流感病毒使感染者病重甚至死亡的机制。相关研究发表在9月16日出版的《细胞》杂志上。
 
       研究人员将这种流感致死的免疫过程称为“细胞因子风暴”,可以预测病毒感染过程的发病率和死亡率,其被认为是1918-1919 年间世界大流感和近来猪流感、禽流感爆发的主因。
 
       在这篇论文中,研究人员利用遗传学和化学手段研究细胞表面受体S1P1。他们意外地发现当控制血管壁内皮细胞的S1P1受体时,会影响细胞因子的释放。而之前科学家猜想细胞因子释放是通过位于肺部的受病毒侵染细胞发生的。
 
       NIH的詹姆斯M ·安德森博士表示,此项工作极大地提高了人们对“细胞因子风暴”生物基础的认识,打开了研发这种致命疾病新疗法的大门。

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    2012-01-19 维他命
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