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Stem cells:MINDY1是多胺的下游靶点,可促进胚胎干细胞自我更新

2018-04-15 MedSci MedSci原创

胚胎干细胞(ESCs)可进行自我更新或分化,而这些过程受到严密调控。既往研究人员报道多胺调节剂AMD1对胚胎干细胞自我更新至关重要。多胺类的腐胺、亚精胺和精胺均是在广泛的细胞生理过程中发挥作用的基础有机阳离子。Christina James等人近日发表在Stem cells上发表一篇相关文章,其对多胺在促进自我更新中的重要作用进行探究,并鉴定出一种在多胺下游发挥作用的新的干细胞调节剂:MINDY1

胚胎干细胞(ESCs)可进行自我更新或分化,而这些过程受到严密调控。既往研究人员报道多胺调节剂AMD1对胚胎干细胞自我更新至关重要。多胺类的腐胺、亚精胺和精胺均是在广泛的细胞生理过程中发挥作用的基础有机阳离子。

Christina James等人近日发表在Stem cells上发表一篇相关文章,其对多胺在促进自我更新中的重要作用进行探究,并鉴定出一种在多胺下游发挥作用的新的干细胞调节剂:MINDY1。

在ESCs中,MINDY1蛋白水平高,而且依赖于高水平的多胺。过表达MINDY1可在缺乏通常所必需的细胞因子LIF的情况下促进ESC自我更新。MINDY1蛋白是异戊基烯基化的,这种修饰是其促进自我更新所必需的。

研究人员还发现Mindy1 RNA是神经前体细胞分化过程中mir-710抑制的靶点。

综上所述,本研究结果表明ESC自我更新需要高水平的多胺,部分是通过促进获得高水平的MINDY1。

原始出处:

Christina James,et al.MINDY1 Is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self‐Renewal.Stem cells.April 12,2018.https://doi.org/10.1002/stem.2830

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    2018-12-15 waiwai3043
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    2018-05-15 维他命
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351234, encodeId=5cad135123483, content=<a href='/topic/show?id=37b083e182b' target=_blank style='color:#2F92EE;'>#胚胎干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83718, encryptionId=37b083e182b, topicName=胚胎干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 17 02:35:00 CST 2018, time=2018-04-17, status=1, ipAttribution=)]
    2018-04-17 changjiu

    学习一下谢谢

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351234, encodeId=5cad135123483, content=<a href='/topic/show?id=37b083e182b' target=_blank style='color:#2F92EE;'>#胚胎干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83718, encryptionId=37b083e182b, topicName=胚胎干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 17 02:35:00 CST 2018, time=2018-04-17, status=1, ipAttribution=)]
    2018-04-17 ailian1202
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干细胞具有多潜能的分化能力,能够在体内、体外分化成不同类型的细胞、组织甚至器官。通过干细胞的异种嵌合技术在猪等大动物体内实现异种再造器官,将为器官移植中供体器官严重短缺提供新的方法。然而,人类胚胎干细胞在异种体内分化潜能尚不完全清楚,细胞存活、分化识别、发育时程等关键问题仍未解决,依然存在严重的技术壁垒。

Cell Stem Cell:这是真正的防癌疫苗!科学家用诱导性多能干细胞研发新型疫苗,能“团灭”轮番入侵的癌细胞

“癌症疫苗”,一直是领域内许多研究人员的梦想。我们现在所见的癌症疫苗一般都是“治疗性疫苗”,通过增强免疫系统攻击肿瘤的能力,减小、甚至消灭肿瘤。然而这和我们认知中的疫苗不太一样,从小到大,我们接种的都是预防性疫苗,将疾病扼杀在摇篮中的那种,那癌症能不能也这样呢?

Genes Dev:胚胎干细胞转化为心肌细胞简便方法被找到!

近日,Salk研究所的科学家们宣布,他们找到了将干细胞快速转化为心肌细胞的简便方法。这项研究于2017年12月21日在《Genes&Development》上发表,为科学家们提供了一种快速获得研究性心肌细胞的简单方法,也为心肌细胞再生疗法的研究提供了希望。

Cell Stem Cell:非经典的BCOR-PRC1.1复合体抑制人胚胎干细胞的分化过程

本研究提高了ESCs中Polycomb靶向和抑制过程理解,并且可以在发育系统中广泛的应用。

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