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J Periodontal Res：虾青素可通过增加成骨细胞活性并降低破骨细胞活性来对抗牙周炎

2017-10-24 MedSci MedSci原创

虾青素牙周炎
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虾青素是具有很强抗氧化作用的酮类胡萝卜素。本研究旨在评估虾青素对结扎诱导的牙周炎大鼠牙槽骨丢失和组织病理学变化的影响。将Wistar大鼠分为4个实验组：未结扎（C，n = 6）；仅结扎（L，n = 6）；结扎和虾青素（1mg/kg/天虾青素，AS1组，n = 8）；结扎和虾青素（5mg/kg/天虾青素，AS5组，n = 8）。丝线结扎部位为下颌第一磨牙。研究时间为11天，结束后处死大鼠。临床评估牙

虾青素是具有很强抗氧化作用的酮类胡萝卜素。本研究旨在评估虾青素对结扎诱导的牙周炎大鼠牙槽骨丢失和组织病理学变化的影响。

将Wistar大鼠分为4个实验组：未结扎（C，n = 6）；仅结扎（L，n = 6）；结扎和虾青素（1mg/kg/天虾青素，AS1组，n = 8）；结扎和虾青素（5mg/kg/天虾青素，AS5组，n = 8）。丝线结扎部位为下颌第一磨牙。研究时间为11天，结束后处死大鼠。临床评估牙槽骨水平的变化，免疫组织化学检查评估组织，评估牙槽骨骨钙素、骨形态发生蛋白-2、诱导型一氧化氮合酶、Bax和bcl-2的水平，对破骨细胞、成骨细胞和炎症细胞进行计数。

结果显示，L组牙槽骨丧失程度最高，L、AS1和AS5组差异有统计学意义（P <0.05）。两种剂量的虾青素均可降低酒石酸耐药性酸性磷酸酶阳性+破骨细胞，增加成骨细胞数量（P <0.05）。 L组炎症也高于C和AS1组（P <0.05），表明虾青素具有抗炎作用。AS5组的诱导型一氧化氮合酶，骨钙素，骨形态发生蛋白-2和bax染色百分比均最高，AS1组bcl-2染色率最高，各组值相近（P> 0.05）。

总之，该研究结果表明，实验性牙周炎模型中，虾青素可以通过增加成骨细胞活性并降低破骨细胞活性来减少牙槽骨的丧失。

原始出处：

Balci Yuce H, Lektemur Alpan A, Gevrek F, Toker H. Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis. J Periodontal Res. 2017 Oct 17. doi: 10.1111/jre.12497.

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    2017-11-02 feather89

    #PE#

    0

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    2017-10-26 ren1mw

    学习一下!谢谢分享!

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-26 lou.minghong

    也能用于骨质疏松吗?

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 caobinglei8079

    #破骨细胞#

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 zhaojie88

    #成骨#

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 liuyong2982

    #牙周#

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 jj000004

    #骨细胞#

    0

  8. 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likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Tue Oct 24 07:11:35 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255499, encodeId=0cb2255499dd, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Oct 24 06:31:53 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255493, encodeId=fbf6255493ea, content=谢谢分享.阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 美丽明天在等我

    虾青素常见于那些食物

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 txqjm

    谢谢了.学习

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Oct 24 06:04:27 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 刘煜

    谢谢分享.阅读

    0

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