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PLoS One:神经影像技术揭示多发性硬化症个体认知损伤的分子机制

2013-11-05 佚名 生物谷

近日,来自凯斯勒基金会的研究者通过研究,揭示了多发性硬化症(MS)个体认知疲劳发生的分子机制,相关研究刊登于国际杂志PLoS ONE上,这项研究首次使用神经影像技术来调查研究个体的认知疲劳发生的过程。【原文下载】 认知疲劳源于脑力劳动,这项研究中,研究者利用三种神经影像技术来揭示和MS个体认知疲劳相关的神经回路,第一种方法是功能性磁共振成像(fMRI)技术,其可以帮助

近日,来自凯斯勒基金会的研究者通过研究,揭示了多发性硬化症(MS)个体认知疲劳发生的分子机制,相关研究刊登于国际杂志PLoS ONE上,这项研究首次使用神经影像技术来调查研究个体的认知疲劳发生的过程。【原文下载】

认知疲劳源于脑力劳动,这项研究中,研究者利用三种神经影像技术来揭示和MS个体认知疲劳相关的神经回路,第一种方法是功能性磁共振成像(fMRI)技术,其可以帮助研究者找到大脑中和任务及经历相关的大脑活性区域;第二种方法是弥散张量成像技术(DTI),其可以帮助研究者找到大脑白质区域;第三种技术是基于像素的形态测量学技术(VBM),其可以帮助研究者调查大脑的结构改变情况。

这三种技术可以被用于检测个体对认知疲劳的反应情况,包括疲劳特点以及疲劳的状态等。这项研究也是首次使用神经影像技术来调查和认知疲劳相关的上述两个方面。

研究者Helen M. Genova博士表示,我们使用了最为先进的神经影像学技术来研究自发疲劳和认识疲劳相关措施之间的关系,这项工作的重要之处就在于阐述了个体认知疲劳的主观感觉和特殊大脑区域之间的大脑活性相关,这就为我们开发相应的干预措施来缓解个体疲劳提供了一定的思路。

通过对认知疲劳相关的大脑区域的识别将帮助研究者重新开发新型的疗法以及对病理生理学进行重新定义,从而改善患者的生活质量及病情变化提供帮助。

原文出处:

Helen M. Genova; Venkateswaran Rajagopalan;John DeLuca;Abhijit Das; Allison Binder;Aparna Arjunan; Nancy Chiaravalloti; Glenn Wylie.Examination of Cognitive Fatigue in Multiple Sclerosis using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging.PLoS ONE 8(11): e78811. doi:10.1371/journal.pone.0078811.【原文下载】

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    2013-12-31 jml2009
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