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JCO:输精管切除术与前列腺癌有关?

2014-07-24 何Jason 医学专业新闻

在线发表于《临床肿瘤学杂志》(JCO)的一项队列研究显示,对于接受了输精管切除术的男性人群,前列腺癌风险将出现增加。该研究共纳入超过50,000个样本。总体而言,输精管切除术与前列腺癌风险增加10%有关,与高度恶性和致死性前列腺癌风险增加20%有关。常规接受PSA筛查的男性群体,该风险甚至增加50%。研究的主要作者,来自哈佛大学公共卫生学院的Lorelei A. Mucci, ScD强调,前列腺癌

在线发表于《临床肿瘤学杂志》(JCO)的一项队列研究显示,对于接受了输精管切除术的男性人群,前列腺癌风险将出现增加。该研究共纳入超过50,000个样本。

总体而言,输精管切除术与前列腺癌风险增加10%有关,与高度恶性和致死性前列腺癌风险增加20%有关。常规接受PSA筛查的男性群体,该风险甚至增加50%。

研究的主要作者,来自哈佛大学公共卫生学院的Lorelei A. Mucci, ScD强调,前列腺癌风险的增加是“较小的”。他说:“随访24年间,致死性前列腺癌的累计发病率增加了1.6%。因此,医生在决定进行输精管切除术之前,应充分权衡利弊。”



来自杜克大学的泌尿科医生Stephen Freedland, MD,此前曾进行前列腺癌相关生活方式风险因子的研究。他认为,医生在决定施行输精管切除术之前应充分告知风险,但关于前列腺癌的风险增加,目前仍无法得出最终结论。

Stephen说:“我们对于接受相关手术的患者,应进行严密的监测。但这项研究并不足以改变我们的治疗模式。”

关于输精管切除术与前列腺癌之间的联系,目前仍存在很大争议。

原始出处:

Siddiqui MM1, Wilson KM1, Epstein MM1, Rider JR1, Martin NE1, Stampfer MJ1, Giovannucci EL1, Mucci LA2.Vasectomy and Risk of Aggressive Prostate Cancer: A 24-Year Follow-Up Study.J Clin Oncol. 2014 Jul 7. pii: JCO.2013.54.8446. [Epub ahead of print]


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    2014-08-05 zhaojie88
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