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Int J Antimicrob Agents:F18玻璃或可有效对抗感染

2017-11-26 MedSci MedSci原创

感染是种植或移植手术中最常见的手术并发症,骨髓炎和其他慢性疾病成了此种手术的一大挑战。在此背景下,具有抗菌特性和生物活性的移植生物材料可能具有重要的临床应用价值。近期,来自LaMaV-UFSCarLaMaV-UFSCar的研究人员研发一种名为F18的玻璃复合物,可加工性范围广,生物活性高。借助于F18研究人员可轻易制造复杂的形状,如支架、连续纤维和植入物涂层。体内试验已证实这种生物材料可用于骨和皮

感染是种植或移植手术中最常见的手术并发症,骨髓炎和其他慢性疾病成了此种手术的一大挑战。在此背景下,具有抗菌特性和生物活性的移植生物材料可能具有重要的临床应用价值。

近期,来自LaMaV-UFSCarLaMaV-UFSCar的研究人员研发一种名为F18的玻璃复合物,可加工性范围广,生物活性高。借助于F18研究人员可轻易制造复杂的形状,如支架、连续纤维和植入物涂层。体内试验已证实这种生物材料可用于骨和皮肤再生的替代品,然而其抗菌能力尚不清楚。

因此,本研究旨在根据JIS Z 2801:2010标准系统地研究粉末和纤维形式的F18的抗菌活性。此外,研究人员还评估了将银掺入F18玻璃中是否会影响其抗菌活性。研究使用了四种临床相关的革兰氏阳性和革兰氏阴性病原菌株(金黄色葡萄球菌、表皮葡萄球菌、大肠杆菌和铜绿假单胞菌)。

结果显示,在粉末和纤维形式中,F18对所有测试菌株都具有极高的杀菌活性,24小时时消除了100%的细菌。动力学试验表明,掺杂银可进一步增强其杀菌活性,30分钟内便可清除金黄色葡萄球菌。

综上所述,该研究结果表明,掺杂和不掺杂银的生物活性玻璃均表现出非常高的杀菌活性,可使F18成为临床中预防感染的骨替代物和伤口再生的替代物。

原始出处:

Souza MT, Campanini LA,et al., Broad-spectrum bactericidal activity of a new bioactive grafting material (F18) against clinically important bacterial strains. Int J Antimicrob Agents. 2017 Dec;50(6):730-733. doi: 10.1016/j.ijantimicag.2017.08.015. Epub 2017 Aug 12.

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    2018-09-10 grace5700
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    2018-04-18 xjy02
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    2018-06-28 wjywjy
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