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J Clin Periodontol：牙龈卟啉单胞菌与心血管疾病之间的相关性

2018-04-05 MedSci MedSci原创

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体外研究显示牙龈卟啉单胞菌（Pg）是一种与牙周炎发病和进展密切相关的病原体，能够激活血小板，从而将牙周炎症与血管健康危害联系起来。由于野生型Pg菌株具有明显的遗传异质性特征，因此牙周炎患者中血小板活化性Pg菌株的共同性目前尚不清楚。因此，本研究评估了从侵袭性牙周炎患者中采集的野生型Pg分离株的血小板活化能力。 通过光透射聚集测定法测定血小板聚集的程度和速度。通过流式细胞术测量P-选择素的血小板表面

体外研究显示牙龈卟啉单胞菌（Pg）是一种与牙周炎发病和进展密切相关的病原体，能够激活血小板，从而将牙周炎症与血管健康危害联系起来。由于野生型Pg菌株具有明显的遗传异质性特征，因此牙周炎患者中血小板活化性Pg菌株的共同性目前尚不清楚。因此，本研究评估了从侵袭性牙周炎患者中采集的野生型Pg分离株的血小板活化能力。

通过光透射聚集测定法测定血小板聚集的程度和速度。通过流式细胞术测量P-选择素的血小板表面表达，使用磷酸特异性抗体通过Western印迹评估p38MAP激酶和蛋白激酶C的活性。

结果显示，Pg分离物在血小板活化的程度和速度以及所涉及的活化途径方面表现出高度可变性。同时观察到血小板P-选择素表达、p38 MAP激酶或蛋白激酶C的激活的相应结果。血小板免疫受体FcγRIIA和蛋白酶活化受体的抑制剂揭示了几种不同的激活途径。即使存在有效的治疗性血小板抑制剂，一些分离物也诱导血小板聚集。

总之，该研究结果表明，涉及特异性血小板活化性Pg菌株的慢性菌血症可或可危害心血管健康。

原始出处：

Jockel-Schneider Y, Kobsar A, et al., Wild-type isolates of Porphyromonas gingivalis derived from periodontitis patients display major variability in platelet activation. J Clin Periodontol. 2018 Apr 2. doi: 10.1111/jcpe.12895. 

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    2018-11-28 feather89

    #PE#

    0

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    2018-06-30 shenxlcyp

    #相关性#

    0

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    2018-04-07 虈亣靌

    学习了.谢谢作者分享!

    0

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    2018-04-07 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-04-07 智慧医人

    #牙龈卟啉单胞菌#

    0

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    2018-04-07 andy2090

    #血管疾病#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1727228, encodeId=69381e272287a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Nov 28 01:20:00 CST 2018, time=2018-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837485, encodeId=0cc3183e485b1, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat Jun 30 02:20:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303590, encodeId=fc08303590ea, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Apr 07 14:59:21 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303428, encodeId=b02230342862, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Apr 07 05:51:07 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361049, encodeId=4221136104958, content=<a href='/topic/show?id=c1006e72663' target=_blank style='color:#2F92EE;'>#牙龈卟啉单胞菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67726, encryptionId=c1006e72663, topicName=牙龈卟啉单胞菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Apr 07 05:20:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498400, encodeId=2e611498400f1, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Apr 07 05:20:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303232, encodeId=6b813032326f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Apr 06 08:29:52 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303012, encodeId=4fa4303012c9, content=该菌体如何分离?, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/02/7ad94af35c47a71c72520c121142446f.jpg, createdBy=c49367641, createdName=ziguoyuan, createdTime=Thu Apr 05 15:00:23 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-06 yfjms

    学习

    0

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    2018-04-05 ziguoyuan

    该菌体如何分离?

    0

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