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中国成功研发全球EV71型手足口病灭活疫苗

2016-03-22 佚名 生物谷

全球首个肠道病毒71型灭活疫苗(人二倍体细胞)正式投入市场。该疫苗的上市,对于有效降低EV71引起的手足口病的发病,尤其是减少手足口病的重症和死亡病例具有重要意义。 肠道病毒71型是人肠道病毒的一种,简称为EV71,常引起儿童手足口病、病毒性咽峡炎,重症患儿可出现心肌炎、肺水肿、脑炎等,严重的会引起死亡。自1981年手足口病在中国出现以来,已发生多次大规模暴发或流行。

全球首个肠道病毒71型灭活疫苗(人二倍体细胞)正式投入市场。该疫苗的上市,对于有效降低EV71引起的手足口病的发病,尤其是减少手足口病的重症和死亡病例具有重要意义。

肠道病毒71型是人肠道病毒的一种,简称为EV71,常引起儿童手足口病、病毒性咽峡炎,重症患儿可出现心肌炎、肺水肿、脑炎等,严重的会引起死亡。自1981年手足口病在中国出现以来,已发生多次大规模暴发或流行。

据中国医学科学院医学生物学研究所所长李琦涵介绍,肠道病毒71型灭活疫苗(人二倍体细胞)是该所自主创新研发的国家预防用生物制品1类新药,于2015年12月获得国家食品药品监督管理总局批准,日前首批疫苗批签合格,正式投入市场使用。

该疫苗为微乳白色混悬液,可因沉淀而分层,易摇散。不仅是全球首个EV71疫苗,也是唯一采用人源性细胞基质生产的EV71疫苗产品。

中国医学科学院医学生物学研究所自2008年开始EV71灭活疫苗的研发工作。在国内外尚无同类疫苗研发上市的情况下,突破了疫苗二倍体细胞规模化生产和质量控制关键技术瓶颈。临床试验结果显示,该疫苗安全性较好,对EV71引起的手足口病的保护率可达97.3%,预防由EV71引起的重症手足口病的保护率为100%。

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    2016-12-04 lingqf
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    2016-03-28 忠诚向上

    好好学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1678323, encodeId=4c2516e83232c, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sun Dec 04 12:33:00 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078824, encodeId=3ac520e882405, content=<a href='/topic/show?id=f48865242bb' target=_blank style='color:#2F92EE;'>#活疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65242, encryptionId=f48865242bb, topicName=活疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Tue May 31 03:33:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985171, encodeId=587019851e106, content=<a href='/topic/show?id=999fe1009a' target=_blank style='color:#2F92EE;'>#EV71#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7100, encryptionId=999fe1009a, topicName=EV71)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Apr 06 01:33:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74297, encodeId=257ae42978d, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74298, encodeId=0dabe4298a6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74299, encodeId=0f86e429943, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74300, encodeId=2c80e43007e, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74301, encodeId=206ee430116, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74302, encodeId=0eb2e43026b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74303, encodeId=5753e430341, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1678323, encodeId=4c2516e83232c, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sun Dec 04 12:33:00 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078824, encodeId=3ac520e882405, content=<a href='/topic/show?id=f48865242bb' target=_blank style='color:#2F92EE;'>#活疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65242, encryptionId=f48865242bb, topicName=活疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Tue May 31 03:33:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985171, encodeId=587019851e106, content=<a href='/topic/show?id=999fe1009a' target=_blank style='color:#2F92EE;'>#EV71#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7100, encryptionId=999fe1009a, topicName=EV71)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Apr 06 01:33:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74297, encodeId=257ae42978d, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74298, encodeId=0dabe4298a6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74299, encodeId=0f86e429943, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74300, encodeId=2c80e43007e, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74301, encodeId=206ee430116, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74302, encodeId=0eb2e43026b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74303, encodeId=5753e430341, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1678323, encodeId=4c2516e83232c, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sun Dec 04 12:33:00 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078824, encodeId=3ac520e882405, content=<a href='/topic/show?id=f48865242bb' target=_blank style='color:#2F92EE;'>#活疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65242, encryptionId=f48865242bb, topicName=活疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Tue May 31 03:33:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985171, encodeId=587019851e106, content=<a href='/topic/show?id=999fe1009a' target=_blank style='color:#2F92EE;'>#EV71#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7100, encryptionId=999fe1009a, topicName=EV71)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Apr 06 01:33:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74297, encodeId=257ae42978d, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74298, encodeId=0dabe4298a6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74299, encodeId=0f86e429943, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74300, encodeId=2c80e43007e, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74301, encodeId=206ee430116, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74302, encodeId=0eb2e43026b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74303, encodeId=5753e430341, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1678323, encodeId=4c2516e83232c, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sun Dec 04 12:33:00 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078824, encodeId=3ac520e882405, content=<a href='/topic/show?id=f48865242bb' target=_blank style='color:#2F92EE;'>#活疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65242, encryptionId=f48865242bb, topicName=活疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Tue May 31 03:33:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985171, encodeId=587019851e106, content=<a href='/topic/show?id=999fe1009a' target=_blank style='color:#2F92EE;'>#EV71#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7100, encryptionId=999fe1009a, topicName=EV71)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Apr 06 01:33:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74297, encodeId=257ae42978d, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74298, encodeId=0dabe4298a6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74299, encodeId=0f86e429943, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=215, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74300, encodeId=2c80e43007e, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74301, encodeId=206ee430116, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74302, encodeId=0eb2e43026b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74303, encodeId=5753e430341, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:46:00 CST 2016, time=2016-03-28, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

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    2016-03-28 忠诚向上

    好好学习一下

    0

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    2016-03-28 忠诚向上

    好好学习一下

    0

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