Baidu
map

JGAM:接受阿奇霉素治疗的肺炎支原体肺炎儿童肠道菌群组成发生改变

2023-03-16 小文子 MedSci原创 发表于上海

基因测序数据揭示了阿奇霉素治疗肺炎支原体肺炎患儿肠道菌群组成的改变。微生物表达的改变与临床特征相关,这可能有助于诊断和治疗该病。

肺炎支原体是引起儿童社区获得性肺炎最重要的病原菌之一,肺炎支原体感染的致病机制复杂。阿奇霉素是治疗获得性下呼吸道感染和泌尿生殖道感染的有效药物,不良反应轻微。The Journal of General and Applied Microbiology杂志发表了一项研究,旨在比较肺炎支原体肺炎患儿阿奇霉素干预前(PP1)和干预后(PP2)肠道菌群变化,结合体液生化分析,确定肠道菌群对疾病进展的影响。

研究招募15例肺炎支原体肺炎患儿,年龄3~10岁。1~3个月内完成健康和饮食习惯调查。在每个患者入院时收集第一批样本,包括粪便、血液和尿液,第二批样本在1个月后收集。使用QIAamp快速DNA粪便迷你试剂盒(QIAGEN)从每个粪便样本中提取基因组DNA。测定DNA含量。

纳入15例肺炎支原体肺炎患儿接受标准治疗(阿奇霉素,每天10 mg/kg体重),3天为1个疗程。所有参与者都连续完成了2个疗程。平均住院时间为8.2±1.97天。

对OUT物种进行分类。结果表明,两组在门、类、目、科、属、和种上存在差异。PP1组的嗜血杆菌属、巴斯德菌目、巴斯德菌科的丰度显著高于PP2组。

皮尔森相关分析表明,微生物与临床特征强烈相关。PP1中较高的中性粒细胞百分比、较低的淋巴细胞百分比和血小板临界值与肠杆菌科、梭菌纲、γ变形杆菌纲的表达丰度呈正相关,而淋巴细胞数量与三种菌株的丰度呈负相关。副流感嗜血杆菌丰度与超敏C反应蛋白水平及单核细胞数呈正相关。巴斯德菌目、巴斯德菌科的丰度与血红蛋白和红细胞压积呈负相关。

基因测序数据揭示了阿奇霉素治疗肺炎支原体肺炎患儿肠道菌群组成的改变。微生物表达的改变与临床特征相关,这可能有助于诊断和治疗该病。

原文出处:

Qiong Deng,Zhu Wang,et al, 16S rRNA gene sequencing reveals an altered composition of gut microbiota in children with Mycoplasma pneumoniae pneumonia treated with azithromycin, J. Gen. Appl. Microbiol., 68, 253–261 (2022),doi 10.2323/jgam.2022.05.004.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2120093, encodeId=6921212009389, content=接受<a href='/topic/show?id=f8729e75210' target=_blank style='color:#2F92EE;'>#阿奇霉素#</a>治疗的<a href='/topic/show?id=c53c821604d' target=_blank style='color:#2F92EE;'>#肺炎#</a><a href='/topic/show?id=9ef95e06950' target=_blank style='color:#2F92EE;'>#支原体肺炎#</a>儿童<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>组成发生改变。PP1组的<a href='/topic/show?id=d656105663fe' target=_blank style='color:#2F92EE;'>#嗜血杆菌属#</a>、<a href='/topic/show?id=06a710566479' target=_blank style='color:#2F92EE;'>#巴斯德菌目#</a>、<a href='/topic/show?id=f53b10566575' target=_blank style='color:#2F92EE;'>#巴斯德菌科#</a>的丰度显著高于PP2组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97752, encryptionId=f8729e75210, topicName=阿奇霉素), TopicDto(id=82160, encryptionId=c53c821604d, topicName=肺炎), TopicDto(id=57069, encryptionId=9ef95e06950, topicName=支原体肺炎), TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=105663, encryptionId=d656105663fe, topicName=嗜血杆菌属), TopicDto(id=105664, encryptionId=06a710566479, topicName=巴斯德菌目), TopicDto(id=105665, encryptionId=f53b10566575, topicName=巴斯德菌科)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Mar 17 07:41:29 CST 2023, time=2023-03-17, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2120091, encodeId=6eb0212009139, content=我认为不光是应用阿奇霉素,只要应用抗生素都会对肠道菌群产生影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201003/146bb24b4baf4558b152e7d9125d7af2/56cb7300721e49f599f03a82e34e98bc.jpg, createdBy=c5a25410119, createdName=ms5000000069254713, createdTime=Fri Mar 17 06:47:50 CST 2023, time=2023-03-17, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2120010, encodeId=cdfe2120010b0, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Thu Mar 16 19:44:56 CST 2023, time=2023-03-16, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2120051, encodeId=8c9b2120051ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Mar 16 21:57:26 CST 2023, time=2023-03-16, status=1, ipAttribution=)]
    2023-03-17 侠胆医心 来自上海

    接受#阿奇霉素#治疗的#肺炎##支原体肺炎#儿童#肠道菌群#组成发生改变。PP1组的#嗜血杆菌属##巴斯德菌目##巴斯德菌科#的丰度显著高于PP2组。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2120093, encodeId=6921212009389, content=接受<a href='/topic/show?id=f8729e75210' target=_blank style='color:#2F92EE;'>#阿奇霉素#</a>治疗的<a href='/topic/show?id=c53c821604d' target=_blank style='color:#2F92EE;'>#肺炎#</a><a href='/topic/show?id=9ef95e06950' target=_blank style='color:#2F92EE;'>#支原体肺炎#</a>儿童<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>组成发生改变。PP1组的<a href='/topic/show?id=d656105663fe' target=_blank style='color:#2F92EE;'>#嗜血杆菌属#</a>、<a href='/topic/show?id=06a710566479' target=_blank style='color:#2F92EE;'>#巴斯德菌目#</a>、<a href='/topic/show?id=f53b10566575' target=_blank style='color:#2F92EE;'>#巴斯德菌科#</a>的丰度显著高于PP2组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97752, encryptionId=f8729e75210, topicName=阿奇霉素), TopicDto(id=82160, encryptionId=c53c821604d, topicName=肺炎), TopicDto(id=57069, encryptionId=9ef95e06950, topicName=支原体肺炎), TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=105663, encryptionId=d656105663fe, topicName=嗜血杆菌属), TopicDto(id=105664, encryptionId=06a710566479, topicName=巴斯德菌目), TopicDto(id=105665, encryptionId=f53b10566575, topicName=巴斯德菌科)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Mar 17 07:41:29 CST 2023, time=2023-03-17, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2120091, encodeId=6eb0212009139, content=我认为不光是应用阿奇霉素,只要应用抗生素都会对肠道菌群产生影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201003/146bb24b4baf4558b152e7d9125d7af2/56cb7300721e49f599f03a82e34e98bc.jpg, createdBy=c5a25410119, createdName=ms5000000069254713, createdTime=Fri Mar 17 06:47:50 CST 2023, time=2023-03-17, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2120010, encodeId=cdfe2120010b0, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Thu Mar 16 19:44:56 CST 2023, time=2023-03-16, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2120051, encodeId=8c9b2120051ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Mar 16 21:57:26 CST 2023, time=2023-03-16, status=1, ipAttribution=)]
    2023-03-17 ms5000000069254713 来自山东省

    我认为不光是应用阿奇霉素,只要应用抗生素都会对肠道菌群产生影响

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2120093, encodeId=6921212009389, content=接受<a href='/topic/show?id=f8729e75210' target=_blank style='color:#2F92EE;'>#阿奇霉素#</a>治疗的<a href='/topic/show?id=c53c821604d' target=_blank style='color:#2F92EE;'>#肺炎#</a><a href='/topic/show?id=9ef95e06950' target=_blank style='color:#2F92EE;'>#支原体肺炎#</a>儿童<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>组成发生改变。PP1组的<a href='/topic/show?id=d656105663fe' target=_blank style='color:#2F92EE;'>#嗜血杆菌属#</a>、<a href='/topic/show?id=06a710566479' target=_blank style='color:#2F92EE;'>#巴斯德菌目#</a>、<a href='/topic/show?id=f53b10566575' target=_blank style='color:#2F92EE;'>#巴斯德菌科#</a>的丰度显著高于PP2组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97752, encryptionId=f8729e75210, topicName=阿奇霉素), TopicDto(id=82160, encryptionId=c53c821604d, topicName=肺炎), TopicDto(id=57069, encryptionId=9ef95e06950, topicName=支原体肺炎), TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=105663, encryptionId=d656105663fe, topicName=嗜血杆菌属), TopicDto(id=105664, encryptionId=06a710566479, topicName=巴斯德菌目), TopicDto(id=105665, encryptionId=f53b10566575, topicName=巴斯德菌科)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Mar 17 07:41:29 CST 2023, time=2023-03-17, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2120091, encodeId=6eb0212009139, content=我认为不光是应用阿奇霉素,只要应用抗生素都会对肠道菌群产生影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201003/146bb24b4baf4558b152e7d9125d7af2/56cb7300721e49f599f03a82e34e98bc.jpg, createdBy=c5a25410119, createdName=ms5000000069254713, createdTime=Fri Mar 17 06:47:50 CST 2023, time=2023-03-17, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2120010, encodeId=cdfe2120010b0, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Thu Mar 16 19:44:56 CST 2023, time=2023-03-16, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2120051, encodeId=8c9b2120051ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Mar 16 21:57:26 CST 2023, time=2023-03-16, status=1, ipAttribution=)]
    2023-03-16 医鸣惊人 来自山西省

    认真学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2120093, encodeId=6921212009389, content=接受<a href='/topic/show?id=f8729e75210' target=_blank style='color:#2F92EE;'>#阿奇霉素#</a>治疗的<a href='/topic/show?id=c53c821604d' target=_blank style='color:#2F92EE;'>#肺炎#</a><a href='/topic/show?id=9ef95e06950' target=_blank style='color:#2F92EE;'>#支原体肺炎#</a>儿童<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>组成发生改变。PP1组的<a href='/topic/show?id=d656105663fe' target=_blank style='color:#2F92EE;'>#嗜血杆菌属#</a>、<a href='/topic/show?id=06a710566479' target=_blank style='color:#2F92EE;'>#巴斯德菌目#</a>、<a href='/topic/show?id=f53b10566575' target=_blank style='color:#2F92EE;'>#巴斯德菌科#</a>的丰度显著高于PP2组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97752, encryptionId=f8729e75210, topicName=阿奇霉素), TopicDto(id=82160, encryptionId=c53c821604d, topicName=肺炎), TopicDto(id=57069, encryptionId=9ef95e06950, topicName=支原体肺炎), TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=105663, encryptionId=d656105663fe, topicName=嗜血杆菌属), TopicDto(id=105664, encryptionId=06a710566479, topicName=巴斯德菌目), TopicDto(id=105665, encryptionId=f53b10566575, topicName=巴斯德菌科)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Mar 17 07:41:29 CST 2023, time=2023-03-17, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2120091, encodeId=6eb0212009139, content=我认为不光是应用阿奇霉素,只要应用抗生素都会对肠道菌群产生影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201003/146bb24b4baf4558b152e7d9125d7af2/56cb7300721e49f599f03a82e34e98bc.jpg, createdBy=c5a25410119, createdName=ms5000000069254713, createdTime=Fri Mar 17 06:47:50 CST 2023, time=2023-03-17, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2120010, encodeId=cdfe2120010b0, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Thu Mar 16 19:44:56 CST 2023, time=2023-03-16, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2120051, encodeId=8c9b2120051ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Mar 16 21:57:26 CST 2023, time=2023-03-16, status=1, ipAttribution=)]
    2023-03-16 仁术2021

    不错,学习了。

    0

相关资讯

Comput Math Methods Med:消银颗粒联合阿奇霉素可更好地治疗寻常型银屑病

银屑病是一种慢性非传染性皮肤病,而寻常型银屑病是最常见的表型。阿奇霉素是治疗银屑病最广泛使用的全身性维甲酸类药物。

梅斯盘点:2022年度中国学者发表的呼吸病学领域的十大进展

2022年度应该是中国呼吸病学领域的腾飞的一年!下面梅斯小编为大家盘点2022年中国呼吸病学领域的十大进展。

NEJM Evid:阿奇霉素预防严重呼吸道合胞病毒性细支气管炎后复发性喘息(APW-RSV II研究)

哮喘是儿童期最常见的慢性疾病,对儿童、他们的家庭和医疗保健系统产生重大影响,因此哮喘预防成为重中之重。生命早期呼吸道合胞病毒 (RSV) 细支气管炎,尤其是严重时,是众所周知的儿童哮喘发展的危险因素。

女子混吃7种感冒止咳药全身长满脓疱

近日,家住深圳的周女士(化名)发现自己出现发热、咽痛、咳嗽等症状,于是将在诊所开的阿奇霉素、克咳平、咳特灵等7种感冒止咳药混合服用。连续服药两天后,她的面部和身上出现了一片片红斑和小脓疱。

NEJM:连续三轮大规模阿奇霉素给药防控雅司病!

以6个月为间隔进行三轮阿奇霉素大规模给药后雅司病社区患病率的降低幅度大于一轮阿奇霉素大规模给药后进行两轮靶向治疗

Baidu
map
Baidu
map
Baidu
map