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Nanoscale Res Lett：新型nHAC/PLGA/GO支架具有良好的细胞相容性和骨再生能力

2018-01-30 MedSci MedSci原创

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可生物降解的多孔生物材料支架在骨再生中起关键作用。本研究采用冷冻干燥法制备了含有不同量GO的多孔纳米羟基磷灰石/胶原/聚乳酸-羟基乙酸共聚物/氧化石墨烯复合支架（nHAC/PLGA/GO）。 结果表明，合成的支架具有三维多孔结构。 GO略微提高了支架的亲水性并增强了其机械强度。与对照样品相比，掺入1.5wt% GO的支架杨氏模量大大增加。体外实验表明，nHAC/PLGA/GO（1.5wt%）支架可

可生物降解的多孔生物材料支架在骨再生中起关键作用。本研究采用冷冻干燥法制备了含有不同量GO的多孔纳米羟基磷灰石/胶原/聚乳酸-羟基乙酸共聚物/氧化石墨烯复合支架（nHAC/PLGA/GO）。

结果表明，合成的支架具有三维多孔结构。 GO略微提高了支架的亲水性并增强了其机械强度。与对照样品相比，掺入1.5wt% GO的支架杨氏模量大大增加。体外实验表明，nHAC/PLGA/GO（1.5wt%）支架可明显增强成骨细胞（MC3T3-E1）的细胞粘附和增殖。

总之，本研究表明，nHAC/PLGA/GO支架具有良好的细胞相容性和骨再生能力，因此在骨组织工程领域具有很高的应用潜力。

原始出处：

Liang C, Luo Y, et al., Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells. Nanoscale Res Lett. 2018 Jan 11;13(1):15. doi: 10.1186/s11671-018-2432-6.

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    2018-02-28 zhangying8788

    #scale#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1793657, encodeId=e7811e936579a, content=<a href='/topic/show?id=e40315955e3' target=_blank style='color:#2F92EE;'>#scale#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15955, encryptionId=e40315955e3, topicName=scale)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Wed Feb 28 09:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704798, encodeId=62411e04798ce, content=<a href='/topic/show?id=0d28143e392' target=_blank style='color:#2F92EE;'>#PLGA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14373, encryptionId=0d28143e392, topicName=PLGA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c02c30837939, createdName=venlin, createdTime=Mon Oct 08 15:36:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037672, encodeId=c871203e67201, content=<a href='/topic/show?id=636d3068e52' target=_blank style='color:#2F92EE;'>#再生能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30687, encryptionId=636d3068e52, topicName=再生能力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Sat Nov 03 15:36:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472111, encodeId=745314e2111b9, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Feb 01 11:36:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
    2018-10-08 venlin

    #PLGA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1793657, encodeId=e7811e936579a, content=<a href='/topic/show?id=e40315955e3' target=_blank style='color:#2F92EE;'>#scale#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15955, encryptionId=e40315955e3, topicName=scale)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Wed Feb 28 09:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704798, encodeId=62411e04798ce, content=<a href='/topic/show?id=0d28143e392' target=_blank style='color:#2F92EE;'>#PLGA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14373, encryptionId=0d28143e392, topicName=PLGA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c02c30837939, createdName=venlin, createdTime=Mon Oct 08 15:36:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037672, encodeId=c871203e67201, content=<a href='/topic/show?id=636d3068e52' target=_blank style='color:#2F92EE;'>#再生能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30687, encryptionId=636d3068e52, topicName=再生能力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Sat Nov 03 15:36:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472111, encodeId=745314e2111b9, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Feb 01 11:36:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
    2018-11-03 124987c6m36暂无昵称

    #再生能力#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1793657, encodeId=e7811e936579a, content=<a href='/topic/show?id=e40315955e3' target=_blank style='color:#2F92EE;'>#scale#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15955, encryptionId=e40315955e3, topicName=scale)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Wed Feb 28 09:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704798, encodeId=62411e04798ce, content=<a href='/topic/show?id=0d28143e392' target=_blank style='color:#2F92EE;'>#PLGA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14373, encryptionId=0d28143e392, topicName=PLGA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c02c30837939, createdName=venlin, createdTime=Mon Oct 08 15:36:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037672, encodeId=c871203e67201, content=<a href='/topic/show?id=636d3068e52' target=_blank style='color:#2F92EE;'>#再生能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30687, encryptionId=636d3068e52, topicName=再生能力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Sat Nov 03 15:36:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472111, encodeId=745314e2111b9, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Feb 01 11:36:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
    2018-02-01 lsj630

    #骨再生#

    0

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