Baidu
map

Adv Rheumatol:研究揭示高安氏动脉炎患者内皮祖细胞和血管内皮生长因子的水平

2019-06-26 不详 网络

内皮祖细胞(EPC)负责内皮损伤修复。Takayasu的动脉炎(TA)是一种影响大血管的慢性炎症性疾病。该研究旨在评估EPC患者的数量和血管内皮生长因子(VEGF)的水平以及这些变量在TA患者中的关系。研究共纳入包括30名TA患者和30名健康对照者。通过流式细胞术和细胞培养评估EPC,并通过商业ELISA试剂盒进行VEGF定量。结果显示,患者和对照组的年龄相似。患者和对照组的EPC数量(中位数(四

内皮祖细胞(EPC)负责内皮损伤修复。Takayasu的动脉炎(TA)是一种影响大血管的慢性炎症性疾病。该研究旨在评估EPC患者的数量和血管内皮生长因子(VEGF)的水平以及这些变量在TA患者中的关系。

研究共纳入包括30名TA患者和30名健康对照者。通过流式细胞术和细胞培养评估EPC,并通过商业ELISA试剂盒进行VEGF定量。

结果显示,患者和对照组的年龄相似。患者和对照组的EPC数量(中位数(四分位数间距)为0.0073%(0.0081%)vs. 0.0062%(0.0089%),流式细胞仪检测为p = 0.779,27.0(42.3)菌落形成单位(CFU)为27.0 (20.5)CFU,细胞培养p = 0.473,患者和对照组VEGF水平为274.5(395.5)pg/ml,相对于243.5(255.3)pg/ml,p = 0.460。患有活动性和非活动性疾病的患者之间的EPC和VEGF水平。服用抗TNFs的患者中成血管细胞样EPC的数量趋于更高;而使用甲氨蝶呤的患者则更低。

总之,该研究结果表明,与对照相比,TA患者中EPC和VEGF水平的定量没有显著差异,并且在患有活动性和非活动性疾病的患者之间没有观察到差异。

原始出处:

Machado LSG, Oliveira ACD, et al., Endothelial progenitor cells and vascular endothelial growth factor in patients with Takayasu's arteritis. Adv Rheumatol. 2018 Aug 9;58(1):24. doi: 10.1186/s42358-018-0025-9.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1683200, encodeId=9a3c168320082, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Sun Sep 22 11:06:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512468, encodeId=3927151246862, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518046, encodeId=bf15151804692, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597133, encodeId=a367159e13306, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
    2019-09-22 xsm927
  2. [GetPortalCommentsPageByObjectIdResponse(id=1683200, encodeId=9a3c168320082, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Sun Sep 22 11:06:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512468, encodeId=3927151246862, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518046, encodeId=bf15151804692, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597133, encodeId=a367159e13306, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1683200, encodeId=9a3c168320082, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Sun Sep 22 11:06:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512468, encodeId=3927151246862, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518046, encodeId=bf15151804692, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597133, encodeId=a367159e13306, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1683200, encodeId=9a3c168320082, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Sun Sep 22 11:06:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512468, encodeId=3927151246862, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518046, encodeId=bf15151804692, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597133, encodeId=a367159e13306, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Fri Jun 28 13:06:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
Baidu
map
Baidu
map
Baidu
map