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Mol Psychiat:新研究发现血液测试或可预测自杀倾向

2015-08-21 sunshine 译 MedSci原创

Molecular Psychiatry:新研究发现血液测试或可预测自杀倾向 近日,来自印第安纳大学医学院的一项新的研究表明,血液测试结合问卷调查或可预测一个人的自杀倾向,且其准确度可达90%,该研究成果发表于《分子精神病学》。研究人员表示,他们已经开发出一种可在病人血液中找到11个生物标志物的简单的测试,将此测试与以应用程序为基础的调查问卷结合时,便可在已接受精神治疗的患者中

近日,来自印第安纳大学医学院的一项新的研究表明,血液测试结合问卷调查或可预测一个人的自杀倾向,且其准确度可达90%,该研究成果发表于《分子精神病学》。
研究人员表示,他们已经开发出一种可在病人血液中找到11个生物标志物的简单的测试,将此测试与以应用程序为基础的调查问卷结合时,便可在已接受精神治疗的患者中预测出谁将会在治疗后两年内仍可产生自杀的念头。


“我们相信,基于健康评估时的这些发现的危险预测测试的广泛采用使得临床医生能够通过干预患者的生活方式或治疗来挽救患者的生命,”共同作者 Alexander B. Niculescu III教授说道。
由于本研究的样本量太小,仅纳入了200名男性加以研究分析,因而并不是所有的科学家认同这一发现。样本量太小意味着在考虑分析比较罕见的条件时得出的结果容易产生偏差。

另一个问题是,如果将这样的测试广泛应用于大众,那么一些假阳性的结果(结果显示某些人可能会自杀,而这些人本身并无自杀的念头)可能会很高。再加上许多不同的环境以及行为因素可增加个体自杀的风险,因此这些结果发现仍不能让很多人信服。

尽管此研究备受争议,但是研究人员仍然对使用生物标志物预测心理健康表现出越来越大的兴趣。就在去年类似的研究表明SKA2基因可用于预测自杀风险,尽管此结论被批判过于简单化。本次新的研究着眼于寻找更广泛的生物标志物并追踪它们在患者精神紊乱(从精神分裂到阿尔茨海默症)接受治疗的几年内其水平的变化情况。此外,它们还分析了26名自杀患者的血液样本。

近年来,很多国家的自杀率都在上升。目前,自杀是导致英国35岁以下男性死亡的一个主要原因,在美国也已达到了历史新高——每12.8分钟便有一人自杀。使得自杀成为了一个非常现实的问题,急需更好的系统加以预测。
 
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    2015-12-04 lyh994

    什么标记物?

    0

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    2015-10-25 三三五五

    感谢!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1753114, encodeId=30e01e53114c5, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Wed Jul 13 03:03:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951113, encodeId=58861951113b2, content=<a href='/topic/show?id=580a89302c6' target=_blank style='color:#2F92EE;'>#血液测试#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89302, encryptionId=580a89302c6, topicName=血液测试)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon Sep 07 01:03:00 CST 2015, time=2015-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44790, encodeId=ca4d44e90d6, content=什么标记物?, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Fri Dec 04 22:02:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41069, encodeId=de4b41069d3, content=感谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Oct 25 14:12:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38663, encodeId=b73e38663b5, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38664, encodeId=fd06386645e, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38381, encodeId=5fd23838144, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:02:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35998, encodeId=68a13599881, content=吼吼, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5iaecibYX9C8bibtETqRvxVQNud0LKVXWwpDY3GzJtHxWqTE33oKEBhoVuYmicqyt9EKbP8vuW5TkINg/0, createdBy=d3331644082, createdName=nina1125, createdTime=Sun Aug 23 13:33:00 CST 2015, time=2015-08-23, status=1, ipAttribution=)]
    2015-10-12 hlycom3356

    这篇文章写的很好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1753114, encodeId=30e01e53114c5, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Wed Jul 13 03:03:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951113, encodeId=58861951113b2, content=<a href='/topic/show?id=580a89302c6' target=_blank style='color:#2F92EE;'>#血液测试#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89302, encryptionId=580a89302c6, topicName=血液测试)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon Sep 07 01:03:00 CST 2015, time=2015-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44790, encodeId=ca4d44e90d6, content=什么标记物?, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Fri Dec 04 22:02:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41069, encodeId=de4b41069d3, content=感谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Oct 25 14:12:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38663, encodeId=b73e38663b5, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38664, encodeId=fd06386645e, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38381, encodeId=5fd23838144, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:02:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35998, encodeId=68a13599881, content=吼吼, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5iaecibYX9C8bibtETqRvxVQNud0LKVXWwpDY3GzJtHxWqTE33oKEBhoVuYmicqyt9EKbP8vuW5TkINg/0, createdBy=d3331644082, createdName=nina1125, createdTime=Sun Aug 23 13:33:00 CST 2015, time=2015-08-23, status=1, ipAttribution=)]
    2015-10-12 hlycom3356

    这篇文章写的很好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1753114, encodeId=30e01e53114c5, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Wed Jul 13 03:03:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951113, encodeId=58861951113b2, content=<a href='/topic/show?id=580a89302c6' target=_blank style='color:#2F92EE;'>#血液测试#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89302, encryptionId=580a89302c6, topicName=血液测试)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon Sep 07 01:03:00 CST 2015, time=2015-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44790, encodeId=ca4d44e90d6, content=什么标记物?, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Fri Dec 04 22:02:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41069, encodeId=de4b41069d3, content=感谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Oct 25 14:12:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38663, encodeId=b73e38663b5, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38664, encodeId=fd06386645e, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38381, encodeId=5fd23838144, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:02:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35998, encodeId=68a13599881, content=吼吼, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5iaecibYX9C8bibtETqRvxVQNud0LKVXWwpDY3GzJtHxWqTE33oKEBhoVuYmicqyt9EKbP8vuW5TkINg/0, createdBy=d3331644082, createdName=nina1125, createdTime=Sun Aug 23 13:33:00 CST 2015, time=2015-08-23, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1753114, encodeId=30e01e53114c5, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Wed Jul 13 03:03:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951113, encodeId=58861951113b2, content=<a href='/topic/show?id=580a89302c6' target=_blank style='color:#2F92EE;'>#血液测试#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89302, encryptionId=580a89302c6, topicName=血液测试)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e12a151, createdName=yangeasy, createdTime=Mon Sep 07 01:03:00 CST 2015, time=2015-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44790, encodeId=ca4d44e90d6, content=什么标记物?, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Fri Dec 04 22:02:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41069, encodeId=de4b41069d3, content=感谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Oct 25 14:12:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38663, encodeId=b73e38663b5, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38664, encodeId=fd06386645e, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:53:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38381, encodeId=5fd23838144, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:02:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35998, encodeId=68a13599881, content=吼吼, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5iaecibYX9C8bibtETqRvxVQNud0LKVXWwpDY3GzJtHxWqTE33oKEBhoVuYmicqyt9EKbP8vuW5TkINg/0, createdBy=d3331644082, createdName=nina1125, createdTime=Sun Aug 23 13:33:00 CST 2015, time=2015-08-23, status=1, ipAttribution=)]
    2015-08-23 nina1125

    吼吼

    0

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