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Pediatr Allergy Immunol: 幼儿期纵向性维生素D缺乏与螨敏感负相关

2017-12-31 AlexYang MedSci原创

关于幼儿中维生素D缺乏的纵向分析以及对特应性疾病的影响的研究很少。最近,有研究人员将155名儿童作为群体进行研究,这些儿童定期在他们的诊所中进行拜访,为期5年。研究人员在他们1.5岁、3岁、4岁和5岁时对他们的血嗜酸粒细胞绝对数目(AEC)、总血清和特异性免疫球蛋白E抗体(针对食物,比如蛋清、牛奶和小麦)和吸入性过面源(D. pteronyssinus、 D. farina和 C. herbaru

关于幼儿中维生素D缺乏的纵向分析以及对特应性疾病的影响的研究很少。最近,有研究人员将155名儿童作为群体进行研究,这些儿童定期在他们的诊所中进行拜访,为期5年。研究人员在他们1.5岁、3岁、4岁和5岁时对他们的血嗜酸粒细胞绝对数目(AEC)、总血清和特异性免疫球蛋白E抗体(针对食物,比如蛋清、牛奶和小麦)和吸入性过面源(D. pteronyssinus、 D. farina和 C. herbarum)进行了测量。

研究总共包括了137名儿童,研究人员对他们进行了血清样获得,并且至少在3个时间点。通过利用k均值聚类方法,维生素D水平的动态变化能够显著的分为3个类别(类别A,≥30ng/ml,n = 61; 类别 B, 20 - 29.9 ng/mL, n = 53; 类别 C, < 20 ng/mL, n = 23)。尽管与特应性疾病没有统计学相关性,3岁时,永久性维生素D缺乏表现出了与嗜酸粒细胞的相关性以及4岁时与总血清和螨特异性lgE水平的相关性。另外,在某个年龄段,更高的螨敏感与过敏性鼻炎和哮喘的风险具有显著的相关性。

最后,研究人员指出,维生素D缺乏与AEC和螨特异性lgE水平负相关,这也许能够潜在的增加幼儿期发展为过敏的可能性,包括了鼻炎和哮喘。

原始出处:

Chiu CY, Su KW, Tsai MH et al. Longitudinal vitamin D deficiency is inversely related to mite sensitization in early childhood. Pediatr Allergy Immunol. 14 Dec 2017.

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    2018-12-06 feather89
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    2018-01-02 膀胱癌
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    2018-01-02 hmwwww
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    2018-01-01 haige

    学习了!找到过敏源真的很重要。

    0

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    2018-01-01 131****1460

    学习了受益匪浅

    0

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