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Arthritis Rheumatol:饮食引起肥胖、代谢失衡和骨关节炎的代际传播

2019-11-25 xiangting MedSci原创

肥胖和骨关节炎(OA)是影响全球数百万人的两个重要公共卫生问题。尽管父母肥胖会影响儿​​童对癌症或糖尿病等疾病的易感性,但人们对诸如OA等肌肉骨骼疾病的跨代影响却知之甚少。   研究了高脂饮食或对照饮食喂养小鼠的第一代(F1)和第二代(F2)后代的代谢表型和OA易感性(每个性别/每种饮食n=10-16)。通过使内侧半月板不稳定来诱导OA。通过组织学确定OA、滑膜炎和脂肪组织炎

肥胖和骨关节炎(OA)是影响全球数百万人的两个重要公共卫生问题。尽管父母肥胖会影响儿​​童对癌症或糖尿病等疾病的易感性,但人们对诸如OA等肌肉骨骼疾病的跨代影响却知之甚少。

研究了高脂饮食或对照饮食喂养小鼠的第一代(F1)和第二代(F2)后代的代谢表型和OA易感性(每个性别/每种饮食n=10-16)。通过使内侧半月板不稳定来诱导OA。通过组织学确定OA、滑膜炎和脂肪组织炎症,而使用microCT测量骨质变化。通过多重测定测量血清和滑膜细胞因子。

父母的高脂喂养对小鼠体重升高(F1高达19%,F2代高达9%)、代谢失衡和损伤诱导OA的遗传有代际影响,尽管后代采用低脂饮食,仍遗传至少两代。令人惊讶的是,F1F2雌性小鼠对损伤引起OA的易感性升高(F1易感性高48%,F2 HFD雌性易感性高19%),并表现出因父母和祖父母高脂喂养引起的骨骼微结构变化。

这项研究揭示了父母高脂饮食和肥胖对后代肌肉骨骼完整性的有害影响,并指出了进一步研究的重要性。进一步了解多代人饮食引起变化可传播性所涉及的机制,有助于未来建立针对肥胖对OA和相关病症影响的疗法。

原始出处:

Natalia S. Harasymowicz. Intergenerational transmission of diet‐induced obesity, metabolic imbalance, and osteoarthritis in mice. Arthritis Rheumatol. October 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2020-01-25 lisa438
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    2019-11-27 lmm397
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    2019-11-27 zhaojie88

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