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Heart:住院的COVID-19患者的肺动脉高压和右心室受累

2020-07-19 MedSci原创 MedSci原创

在COVID-19非ICU住院患者中,PH(而非RVD)与更严重的COVID-19体征和较差的院内临床预后有关。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这项研究旨在评估2019年冠状病毒病(COVID-19)非重症监护病房(ICU)住院患者的肺动脉高压(PH)和右心室功能障碍(RVD)患病率、特征和预后价值。

这项单中心、观察性、横断面研究纳入了211例接受单次胸腔超声心动图检查(TTE)的COVID-19非ICU住院患者。排除了声学窗较差(n=11)的患者。研究人员比较了有无PH(估计的收缩期肺动脉压>35 mmHg)和有无RVD(三尖瓣环平面收缩压<17 mm或S波<9.5 cm/s)患者的临床、影像学、实验室检查和TTE结果。该研究的主要终点是院内死亡或ICU入院。

该研究的最终分析共纳入了200例患者(中位年龄为62岁(IQR为52-74岁),男性占65.5%)。PH和RVD的患病率分别为12.0%(24/200)和14.5%(29/200)。与无PH的患者相比,PH患者年龄较大,既往有心脏病合并症的负担也更重,并且有更严重的严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)感染体征(放射性肺受累、实验室检查和氧合状态) 。与没有RVD的患者相比,RVD的患者有更高的既往心脏合并症负担,但没有证据表明SARS-CoV-2感染更为严重。PH的存在与院内死亡或ICU入院率较高相关(41.7 vs. 8.5%,p<0.001),而RVD则与之不相关(17.2 vs. 11.7%,p=0.404)。

由此可见,在COVID-19非ICU住院患者中,PH(而非RVD)与更严重的COVID-19体征和较差的院内临床预后有关。

原始出处:

Matteo Pagnesi.et al.Pulmonary hypertension and right ventricular involvement in hospitalised patients with COVID-19.heart.2020.https://heart.bmj.com/content/early/2020/07/16/heartjnl-2020-317355

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    2020-07-21 zhaojie88
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    2020-07-21 slcumt
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    2020-07-19 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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