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7月20号,共有三种新冠疫苗经实验证明可以产生免疫反应!

2020-07-21 MedSci原创 MedSci原创

7.20号,共有三种不同类型的冠状病毒疫苗经实验证明都可以产生预期的免疫反应,保护人们免受感染。

7月20号,《柳叶刀》同时发表了两篇疫苗临床实验结果,分别是牛津大学和阿斯利康公司开发的新冠疫苗的1/2期试验结果,中国公司CanSino Biologics生产的一种候选疫苗的2期结果。这两种疫苗经实验证明是安全的,并且能诱导免疫反应。

其中,牛津ChAdOx1 nCoV-19疫苗在28天内促使抗体反应,14天内促使T细胞反应。第一次注射疫苗后,大部分参与者可以产生中和抗体;在第二次注射疫苗后,所有参与者均产生中和抗体。

ELISA检测抗体反应

 

中国公司CanSino Biologics生产的Ad5载体COVID-19疫苗在28天内促使抗体反应。在这项研究中,单次注射1×1011病毒颗粒和5×1010病毒颗粒的Ad5载体COVID-19疫苗,分别诱导了59%和47%的参与者的中和抗体的血清转换,以及96%和97%的参与者的结合抗体的血清转换。1×1011病毒颗粒剂量组中95%的受试者和5×1010病毒颗粒剂量组中91%的受试者在接种后第28天出现细胞或体液免疫反应。

 

RBD的特异性抗体反应,接种后对COVID-19活病毒和伪病毒的中和抗体。

 

         

 用ELISpot测量的特异性T细胞反应

辉瑞和BioNTech生产的疫苗的1/2期试验的早期结果也在一篇尚未经过同行评审的预印论文中发布。

参考文献:

1,Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

DOI:https://doi.org/10.1016/S0140-6736(20)31604-4

2,Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2

DOI:https://doi.org/10.1016/S0140-6736(20)31605-6trial 

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    2021-08-25 ms8000001467349717

    好消息

    0

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    2021-02-27 ms8000001094792874

    怎样才能让讯息提速?这都是半年前的事情了。

    0

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    2020-09-21 子沐

    希望疫苗早点上市

    0

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    2020-08-19 ms8000001384237252

    好消息

    0

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    2020-07-30 岁月静好

    非常好

    0

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    2020-07-28 124d9e69m07暂无昵称

    好消息

    0

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    2020-07-27 你好

    厉害

    0

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    2020-07-23 清海

    希望中国的医学越来越好

    0

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    2020-07-21 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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